Abstract | BACKGROUND: The formation of hypertrophic scar is due to the abnormal accumulation and remodeling of the extracellular matrix, especially collagen tissue. Our research was designed to investigate the treatment effect of different administrations of human umbilical cord-derived stem cells and to hypertrophic scars on rabbit ears. METHODS: Thirty New Zealand female white rabbits were treated as hypertrophic scar models. PBS was injected into the scars on the right ear of each group as control, while human umbilical cord-derived stem cells or condition medium of human umbilical cord-derived stem cells were administrated into the left ear through subcutaneous injection or fractional laser-assisted administration. Gross examination, scar elevation index (SEI) calculation and sampling were executed 5 weeks after administration. Then H&E and Masson staining analysis and the expression levels detections of α-SMA, Collagen I, TGF-β1, IL-1β, and IL-6 were performed. RESULTS: CONCLUSIONS: The results confirmed that stem cells had an available treatment effect on hypertrophic scars of rabbit ears. In addition to the paracrine pathway, stem cells may have other ways to treat hypertrophic scars. Fractional laser-assisted administration may become a potential administration of stem cell clinical application in the future.
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Authors | Hongpeng Zhang, Hao Wang, Cuibao Jiang, Hongwei Wang, Yong Xia, Danpeng Shen, Fan Xie, Nianmin Qi, Kaiyang Lv |
Journal | Lasers in surgery and medicine
(Lasers Surg Med)
Vol. 54
Issue 4
Pg. 554-564
(04 2022)
ISSN: 1096-9101 [Electronic] United States |
PMID | 34962300
(Publication Type: Journal Article)
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Copyright | © 2021 Wiley Periodicals LLC. |
Chemical References |
- Culture Media, Conditioned
- Collagen
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Topics |
- Animals
- Cicatrix, Hypertrophic
(pathology, therapy)
- Collagen
- Culture Media, Conditioned
- Female
- Humans
- Lasers
- Mesenchymal Stem Cells
- Rabbits
- Umbilical Cord
(metabolism, pathology)
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