Abstract | PURPOSE: This study aims to analyze the association between VDR gene polymorphism and the occurrence of " low bone density (LBD)/ osteopenia/ osteoporosis" or LBDOO in type 2 diabetes (T2D) patients among a clustered population in northwest of Iran. The studied VDR gene polymorphism included ApaI (rs7975232), BsmI (rs1544410), FokI (rs2228570), EcoRV (rs4516035) and, TaqI (rs731236). METHODS: In this population-based cross-sectional study, patients with T2D were identified within a group of 1266 participants based on self-report of diabetes, history of diabetes medication, and recorded laboratory data. Separately for each polymorphism and gender, crude and adjusted (age, BMI) odds ratios ( ORs) were calculated for participants with T2D through logistic regression analysis. RESULTS: The prevalence of T2D was 16.41% in people residing in the city of Sanandaj in 2011. Of the participants with T2D, 13.92% and 81.29% had osteoporosis and vitamin D deficiency, respectively. In women, the tt genotype of the TaqI gene significantly decreased the risk of LBDOO versus the Tt genotype, after adjusting for BMI and age (adjusted OR:0.18, CI95%: 0.03-0.97). Conversely, the EE genotype of the EcoRV gene enhanced the risk of LBDOO versus the Ee genotype (adjusted OR:7.64, CI95%: 2.03-28.72). CONCLUSION: The polymorphism of both TaqI and EcoRV genes was associated with the risk of LBDOO in women with T2D. This is the first time a study has highlighted this effect for the polymorphism of the EcoRV gene; we believe that this study would serve as a basis for future studies.
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Authors | Maryam Ghodsi, Abbas Ali Keshtkar, Farideh Razi, Mahsa Mohammad Amoli, Ensieh Nasli-Esfahani, Fariba Zarrabi, Patricia Khashayar, Alireza Khajavi, Bagher Larijani, Mohamad Reza Mohajeri-Tehrani |
Journal | Journal of diabetes and metabolic disorders
(J Diabetes Metab Disord)
Vol. 20
Issue 2
Pg. 1375-1383
(Dec 2021)
ISSN: 2251-6581 [Print] Switzerland |
PMID | 34900789
(Publication Type: Journal Article)
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Copyright | © Springer Nature Switzerland AG 2021. |