Temporal Dynamics of Anti-Type 1 Interferon Autoantibodies in Patients With Coronavirus Disease 2019.

Abstract

Binding levels and neutralization activity of anti-type 1 interferon autoantibodies peaked during acute coronavirus disease 2019 and markedly decreased thereafter. Most patients maintained some ability to neutralize type 1 interferon into convalescence despite lower levels of binding immunoglobulin G. Identifying these autoantibodies in healthy individuals before the development of critical viral disease may be challenging.

• Authors: Elana R Shaw, Lindsey B Rosen, Aristine Cheng, Kerry Dobbs, Ottavia M Delmonte, Elise M N Ferré, Monica M Schmitt, Luisa Imberti, Virginia Quaresima, Michail S Lionakis, Luigi D Notarangelo, Steven M Holland, Helen C Su
• Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 75 Issue 1 Pg. e1192-e1194 (08 24 2022) ISSN: 1537-6591 [Electronic] United States
• PMID: 34875033 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Intramural)
• Copyright: Published by Oxford University Press for the Infectious Diseases Society of America 2021.

Chemical References

• Autoantibodies
• Immunoglobulin G
• Interferon Type I
• Interferon-alpha

Topics

• Autoantibodies
• COVID-19
• Humans
• Immunoglobulin G
• Interferon Type I
• Interferon-alpha