Serum interleukin-17 predicts severity and prognosis in patients with community acquired pneumonia: a prospective cohort study.

Abstract

BACKGROUND:

Some studies previously demonstrated that interleukin-17 (IL-17) involves in pulmonary diseases progression. Nevertheless, the role of IL-17 in community-acquired pneumonia (CAP) remains unknown. This study aims to examine the correlations between serum IL-17 with the severity and prognosis in CAP patients through a prospective cohort study.

METHODS:

All 239 CAP patients were recruited. Serum IL-17 was detected by enzyme-linked immunosorbent assay (ELISA). The CAP severity was evaluated through CAP severity scores, including CURB-65, CRB-65, PSI, SMART-COP, CURXO and APACHE II.

RESULTS:

Serum IL-17 was gradually increased consistent with the severity of CAP. Correlative analysis suggested that serum IL-17 was associated with clinical physiologic indicators among CAP patients. Logistic regression indicated that serum IL-17 was positively related to CAP severity scores. Additionally, the prognostic outcomes were tracked among CAP patients. The levels of IL-17 on admission were significantly increased in CAP patients with ICU admission, mechanical ventilation, vasoactive agent, death and longer hospitalization days. Logistic regression analyses revealed serum higher IL-17 on admission elevated the risks of vasoactive agent usage and longer hospital stays in CAP patients. The cut-off concentrations of serum IL-17 for death, ICU admission, mechanical ventilation and ≥ 14 hospital stays were 86.80 ng/mL, 84.92 ng/mL, 84.92 ng/mL and 60.29 ng/mL respectively.

CONCLUSIONS:

Serum IL-17 on admission is positively associated with the severity and poor prognosis among CAP patients, revealing that IL-17 may implicate in the pathological process of CAP. Therefore, serum IL-17 may become an effective biomarker for diagnosis, prognosis and therapy for CAP patients.

• Authors: Chun-Mei Feng, Xin-Ming Wang, Meng-Die Li, Zheng Xu, Dong-Xu Hua, Jia-Yi Cheng, Ling Zheng, Hui Zhao, Lin Fu
• Journal: BMC pulmonary medicine (BMC Pulm Med) Vol. 21 Issue 1 Pg. 393 (Dec 02 2021) ISSN: 1471-2466 [Electronic] England
• PMID: 34856971 (Publication Type: Journal Article)
• Copyright: © 2021. The Author(s).

Chemical References

• Interleukin-17

Topics

• Aged
• Cohort Studies
• Community-Acquired Infections (blood)
• Female
• Humans
• Interleukin-17 (blood)
• Male
• Middle Aged
• Pneumonia (blood)
• Prognosis
• Prospective Studies
• Severity of Illness Index