Chronic obstructive pulmonary disease and COVID-19: interrelationships.

Abstract

PURPOSE OF REVIEW:

Chronic obstructive pulmonary disease (COPD) and COVID-19 have many potentially negative interrelationships, which may influence the course of infection and clinical outcomes. The aim of this review is to provide clinicians with an up-to-date perspective of the complex interactions between COPD and COVID-19.

RECENT FINDINGS:

We consider mechanisms that could increase SARS-CoV-2 infection susceptibility in COPD, including increased ACE2 expression, reduced antiviral defence and dysfunctional immunity. We review evidence that COPD is associated with worse clinical outcomes from COVID-19 in analyses that have adjusted for confounding factors, and describe the mechanisms responsible. We discuss the use of inhaled corticosteroids in the context of susceptibility to COVID-19, and consider the impact of COVID-19 on the usual care of COPD patients.

SUMMARY:

The current review highlights the evidence that COPD patients have worse outcomes from COVID-19, and the multiple mechanisms responsible.

• Authors: Dave Singh, Alexander G Mathioudakis, Andrew Higham
• Journal: Current opinion in pulmonary medicine (Curr Opin Pulm Med) Vol. 28 Issue 2 Pg. 76-83 (03 01 2022) ISSN: 1531-6971 [Electronic] United States
• PMID: 34690257 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.

Chemical References

• Adrenal Cortex Hormones

Topics

• Adrenal Cortex Hormones (therapeutic use)
• COVID-19
• Humans
• Pulmonary Disease, Chronic Obstructive (drug therapy, epidemiology)
• SARS-CoV-2