Effect of insulin resistance on lung function in asthmatic children.

Abstract

OBJECTIVES:

Insulin resistance may be associated with impaired lung function. The objective of this study was to examine the relationship between insulin resistance and lung function in asthmatic children.

METHODS:

We performed a cross-sectional study on asthmatic children aged 6-18 years at Tertiary Care Center, India. Fasting serum glucose and insulin levels were analyzed to calculate the homeostatic model assessment of insulin resistance (HOMA-IR) in 90 children. Lung function tests were performed. Spearman correlation was used to assess the relationship between insulin resistance and lung function. Linear regression was done to adjust the potential confounders.

RESULTS:

Insulin resistance was present in 15.5% of patients. We found a statistically significant inverse relationship between HOMA-IR and spirometric parameters such as forced expiratory volume in 1 s/forced vital capacity ratio and forced expiratory flow between 25 and 75% on Spearman correlation. However, adjusted regression for age, gender, and body mass index showed no significant association of lung function parameters with HOMA-IR.

CONCLUSIONS:

Insulin resistance may be considered for the decline in lung function in asthmatic children.

• Authors: Jagdish Prasad Goyal, Prawin Kumar, Chirag Thakur, Daisy Khera, Kuldeep Singh, Praveen Sharma
• Journal: Journal of pediatric endocrinology & metabolism : JPEM (J Pediatr Endocrinol Metab) Vol. 35 Issue 2 Pg. 217-222 (Feb 23 2022) ISSN: 2191-0251 [Electronic] Germany
• PMID: 34598376 (Publication Type: Journal Article)
• Copyright: © 2021 Walter de Gruyter GmbH, Berlin/Boston.

Topics

• Adolescent
• Asthma (physiopathology)
• Body Mass Index
• Child
• Cross-Sectional Studies
• Female
• Forced Expiratory Volume
• Humans
• Insulin Resistance
• Lung (physiopathology)
• Male
• Vital Capacity