Piperine Improves Obesity by Inhibiting Fatty Acid Absorption and Repairing Intestinal Barrier Function.

Abstract

Currently, the weight loss effects of piperine have gained considerable attention; however, the underlying mechanism needs to be comprehensively elucidated. In the present study, we aimed to investigate the relationship between the weight loss effects of piperine and intestinal function. Based on the obtained results, piperine inhibited intestinal fatty acid absorption in both cellular and animal models. The underlying mechanism may be related to the downregulation of fatty acid absorption-related genes, fatty acid-binding protein 2 and cluster of differentiation 36, but not fatty acid transport protein 4. In addition, piperine repaired the tight junction damage induced by obesity by downregulating jejunal tumor necrosis factor-α and reducing lipopolysaccharide-induced damage on intestinal cell proliferation, thus enhancing intestinal barrier function, which is beneficial in reducing chronic inflammation associated with obesity. In conclusion, the anti-obesity effect of piperine is related to the enhancement of intestinal barrier function and inhibition of intestinal fatty acid absorption.

• Authors: Wenli Wang, Yanhua Zhang, Xiong Wang, Huilian Che, Yali Zhang
• Journal: Plant foods for human nutrition (Dordrecht, Netherlands) (Plant Foods Hum Nutr) Vol. 76 Issue 4 Pg. 410-418 (Dec 2021) ISSN: 1573-9104 [Electronic] Netherlands
• PMID: 34591253 (Publication Type: Journal Article)
• Copyright: © 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Chemical References

• Alkaloids
• Benzodioxoles
• Fatty Acids
• Piperidines
• Polyunsaturated Alkamides
• piperine

Topics

• Alkaloids
• Animals
• Benzodioxoles (metabolism, pharmacology)
• Fatty Acids (metabolism)
• Intestinal Absorption
• Intestinal Mucosa (metabolism)
• Obesity (drug therapy, metabolism)
• Piperidines
• Polyunsaturated Alkamides (metabolism, pharmacology)