The Indication of Poor Prognosis by High Expression of ENO1 in Squamous Cell Carcinoma of the Lung.

Abstract

The purpose of this study is to investigate the significance of alpha-enolase (ENO1) expression in squamous cell carcinoma of the lung (LUSC), its prognostic value, and prospective molecular mechanism. Using multiplatforms data, including in-house immunohistochemistry, in-house real-time fluorescence quantitative polymerase chain reaction (RT-qPCR), in-house microarray, and public high-throughput data, the expression significance and prognostic role of ENO1 in LUSC tissues were analyzed comprehensively. With the combination of all eligible cases, compared with 941 non-LUSC lung tissues, ENO1 was significantly overexpressed in 1163 cases of LUSC (standardized mean difference (SMD) = 1.23, 95% confidence interval (CI) = 0.76-1.70, P < 0.001). ENO1 also displayed a great ability to differentiate LUSC tissues from non-LUSC lung tissues (AUC = 0.8705) with the comprehensive sensitivity being 0.88 [0.83-0.92], and comprehensive specificity being 0.89 [0.84-0.94]). Moreover, in 1860 cases of LUSC with survival information, patients with higher expression of ENO1 had poorer prognosis (hazard ratio (HR) = 1.20, 95% CI = 1.01-1.43, P = 0.043). ENO1 and its related genes mainly participated in the pathways of cell division and proliferation. In conclusion, the upregulation of ENO1 could affect the carcinogenesis and unfavorable outcome of LUSC.

• Authors: Wan-Ying Huang, Gang Chen, Shang-Wei Chen, Yi-Wu Dang, Yun Deng, Hua-Fu Zhou, Jin-Liang Kong, Yu Zhang, Jun-Xian Mo, Chang-Bo Li, Juan He
• Journal: Journal of oncology (J Oncol) Vol. 2021 Pg. 9910962 ( 2021) ISSN: 1687-8450 [Print] Egypt
• PMID: 34504528 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 Wan-Ying Huang et al.