The role of selenium and vitamin E in a Transylvanian enzootic equine recurrent rhabdomyolysis syndrome.
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| Abstract |
A severe form of recurrent exertional rhabdomyolysis occurs enzootically in a well-defined region of Transylvania, Harghita county. At the highest lying two settlements (more than 800 m above sea level), the prevalence of equine rhabdomyolysis is between 17 and 23%, while in the neighbouring villages in the valley it is less than 2%. The objective of our study was to clarify the role of selenium and vitamin E in the high prevalence of rhabdomyolysis in that region. Soil and hay samples were collected from each area to evaluate mineral content. Ten horses from the non-affected and 20 horses from the affected area were tested for serum selenium, vitamin E, glutathione peroxidase (GSH-Px), muscle enzymes, lactate and electrolytes. Hay samples collected from the affected area had lower selenium content. Horses in the affected regions had significantly lower serum selenium (P = 0.006) and GSH-Px levels than animals living in the non-affected regions. A good correlation between erythrocyte GSH-Px and serum selenium concentration could be demonstrated (r = 0.777, P < 0.001). Serum vitamin E levels were low independently of the origin of the horse. Based on our results, selenium deficiency possibly has a role in the Transylvanian enzootic equine recurrent rhabdomyolysis syndrome.
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| Authors | Csaba Attila Kósa, Krisztina Nagy, Ottó Szenci, Boglárka Baska-Vincze, Emese Andrásofszky, Róbert Szép, Ágnes Keresztesi, Mircea Mircean, Marian Taulescu, Orsolya Kutasi |
| Journal | Acta veterinaria Hungarica (Acta Vet Hung) Vol. 69 Issue 3 Pg. 256-265 (09 07 2021) ISSN: 0236-6290 [Print] Hungary |
| PMID | 34491901 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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