D-ribose-L-cysteine prevents oxidative stress and cardiometabolic syndrome in high fructose high fat diet fed rats.

Abstract

Cardiometabolic syndrome has been linked with dietary modification. Therefore, we investigated the effects of D-ribose-L-cysteine (DRLC) in rats fed with high fructose high fat (HFHF) diet. Twenty rats (n = 5), divided into 4 groups were concurrently exposed to HFHF and/or DRLC (250 mg/kg, p.o) during the 8 weeks study. The result showed that compared to control group, HFHF group had significant impairment in lipid and glucose homeostasis, increased cardiac xanthine oxidase, systolic blood pressure, heart rate, %body weight change and fluid intake. Also, there were significant reductions in HDL-C, cardiac (GPX, NO&GGT), feed intake and relative heart weight in the latter, relative to the former. However, there were no significant differences in most of the observed physical and biochemical changes in HFHF + DRLC group compared to control. DRLC alone did not disrupt the level of biomarkers. Conclusively, DRLC prevented the manifestation of oxidative stress and cardiometabolic syndrome in HFHF-diet fed rats.

• Authors: Abodunrin Adebayo Ojetola, Wale Johnson Adeyemi, Ubong Edem David, Temitayo Olabisi Ajibade, Olumuyiwa Abiola Adejumobi, Temidayo Olutayo Omobowale, Ademola Adetokunbo Oyagbemi, Adesoji Adedipe Fasanmade
• Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (Biomed Pharmacother) Vol. 142 Pg. 112017 (Oct 2021) ISSN: 1950-6007 [Electronic] France
• PMID: 34399203 (Publication Type: Journal Article)
• Copyright: Copyright © 2021. Published by Elsevier Masson SAS.

Chemical References

• Thiazolidines
• 2-(1',2',3',4'-tetrahydroxybutyl)thiazolidine-4-carboxylic acid
• Fructose
• Xanthine Oxidase
• Glucose
• Cysteine

Topics

• Animals
• Blood Pressure (physiology)
• Cysteine (analogs & derivatives, pharmacology)
• Diet, High-Fat (adverse effects)
• Fructose
• Glucose (metabolism)
• Heart Rate (physiology)
• Lipid Metabolism (drug effects)
• Male
• Metabolic Syndrome (etiology, prevention & control)
• Oxidative Stress (drug effects)
• Rats
• Rats, Wistar
• Thiazolidines (pharmacology)
• Xanthine Oxidase (metabolism)