Abstract | SCOPE: METHODS: RESULT: Our results showed that resveratrol attenuates microglia activation and M1 polarization in rotenone-induced BV-2 cells. Rotenone induced the production of free iron, ROS and MDA and inhibited the activity of glutathione, while the effects were reserved by resveratrol. Resveratrol also inhibited the induction effect of rotenone on IL-6, IL-1β, and TNF-α. In addition, resveratrol enhanced the protective effect of on rotenone-induced BV-2 cells via the inhibition of STAT1 and Keap1 and the upregulation of Nrf2 and SLC7A11. CONCLUSION:
Resveratrol attenuated rotenone-induced inflammation and oxidative stress in BV-2 cells through enhancing the inhibition of STAT1and Keap1 and the upregulation of Nrf2 and SLC7A11.
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Authors | Huihua Li, Yujun Shen, Hui Xiao, Wei Sun |
Journal | Pathology, research and practice
(Pathol Res Pract)
Vol. 225
Pg. 153576
(Sep 2021)
ISSN: 1618-0631 [Electronic] Germany |
PMID | 34391968
(Publication Type: Journal Article)
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Copyright | Copyright © 2021. Published by Elsevier GmbH. |
Chemical References |
- Amino Acid Transport System y+
- Antioxidants
- Kelch-Like ECH-Associated Protein 1
- NF-E2-Related Factor 2
- Reactive Oxygen Species
- STAT1 Transcription Factor
- Slc7a11 protein, mouse
- Malondialdehyde
- Resveratrol
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Topics |
- Amino Acid Transport System y+
(metabolism)
- Animals
- Antioxidants
(pharmacology, therapeutic use)
- Cell Line
- Inflammation
(drug therapy, metabolism)
- Kelch-Like ECH-Associated Protein 1
(metabolism)
- Malondialdehyde
(metabolism)
- Mice
- Microglia
(drug effects, metabolism)
- NF-E2-Related Factor 2
(metabolism)
- Oxidative Stress
(drug effects)
- Reactive Oxygen Species
(metabolism)
- Resveratrol
(pharmacology, therapeutic use)
- STAT1 Transcription Factor
(metabolism)
- Signal Transduction
(drug effects)
|