Abstract | PURPOSE: METHODS: This is a prospective, double-blinded, placebo-controlled, randomized clinical trial. We investigated 54 patients scheduled to undergo elective abdominal hysterectomy. Patients were randomly assigned to receive either oral allopurinol 300 mg (n = 27) or placebo (n = 27) the night before and 1 h before surgery. Patients were submitted to evaluation of pain and anxiety before the treatment, for 24 h postoperatively, 30 and 90 days after surgery. Cerebrospinal fluid was collected at the time of the spinal anesthesia to perform the measurement of the central levels of purines. RESULTS: Preoperative administration of allopurinol was effective in reducing postoperative pain 2 h after surgery. Allopurinol caused a reduction of approximately 40% in pain scores measured by the visual analogue pain scale after surgery (p < 0.05). No differences were found between groups in anxiety scores after surgery. There was a significant change in the cerebrospinal fluid concentrations of xanthine and uric acid before surgery (p < 0.01). CONCLUSION: This study showed a short-term benefit of the use of allopurinol as a preanesthetic medication since it was related to a reduction on pain scores 2 h after surgery. The purinergic system is a potential target for new analgesic drugs. New studies investigating more selective purine derivatives in the management of pain should be performed. TRIAL NUMBER REGISTRATION: Brazilian Registry of Clinical Trials-ReBEC #RBR-9pw58p.
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Authors | André P Schmidt, Enderson D de Oliveira, Aécio C Fagundes, Gisele Hansel, Renata O Pedrini, Aline Valdameri, Eduarda S Martinelli, Sérgio R G Schmidt, Cristiano F Andrade, Diogo R Lara, Diogo O Souza |
Journal | Journal of anesthesia
(J Anesth)
Vol. 35
Issue 6
Pg. 818-826
(12 2021)
ISSN: 1438-8359 [Electronic] Japan |
PMID | 34390392
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2021. Japanese Society of Anesthesiologists. |
Chemical References |
- Allopurinol
- Xanthine Oxidase
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Topics |
- Allopurinol
- Double-Blind Method
- Female
- Humans
- Hysterectomy
(adverse effects)
- Pain, Postoperative
(drug therapy, prevention & control)
- Prospective Studies
- Xanthine Oxidase
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