Natural Products with Tandem Anti-inflammatory, Immunomodulatory and Anti-SARS-CoV/2 Effects: A Drug Discovery Perspective against SARS-CoV-2.

Abstract

BACKGROUND:

COVID-19 is still causing long-term health consequences, mass deaths, and collapsing healthcare systems around the world. There are no efficient drugs for its treatment. However, previous studies revealed that SARS-CoV-2 and SARS-CoV have 96% and 86.5% similarities in cysteine proteases (3CLpro) and papain-like protease (PLpro) sequences, respectively. This resemblance could be important in the search for drug candidates with antiviral effects against SARS-CoV-2.

OBJECTIVE:

This paper is a compilation of natural products that inhibit SARS-CoV 3CLpro and PLpro and, concomitantly, reduce inflammation and/or modulate the immune system as a perspective strategy for COVID-19 drug discovery. It also presents in silico studies performed on these selected natural products using SARS-CoV-2 3CLpro and PLpro as targets to propose a list of hit compounds.

METHODS:

The plant metabolites were selected in the literature based on their biological activities on SARS-CoV proteins, inflammatory mediators, and immune response. The consensus docking analysis was performed using four different packages.

RESULTS:

Seventy-nine compounds reported in the literature with inhibitory effects on SARS-CoV proteins were reported as anti-inflammatory agents. Fourteen of them showed immunomodulatory effects in previous studies. Five and six of these compounds showed significant in silico consensus as drug candidates that can inhibit PLpro and 3CLpro, respectively. Our findings corroborated recent results reported on anti-SARS-CoV-2 in the literature.

CONCLUSION:

This study revealed that amentoflavone, rubranoside B, savinin, psoralidin, hirsutenone, and papyriflavonol A are good drug candidates for the search of antibiotics against COVID-19.

• Authors: Luana N O Leal da Cunha, Tiago Tizziani, Gabriella B Souza, Monalisa A Moreira, José S S Neto, Carlos V D Dos Santos, Maryelle G de Carvalho, Eduardo M Dalmarco, Leonardo B Turqueti, Marcus Tullius Scotti, Luciana Scotti, Francisco F de Assis, Antonio Luiz Braga, Louis Pergaud Sandjo
• Journal: Current medicinal chemistry (Curr Med Chem) Vol. 29 Issue 14 Pg. 2530-2564 ( 2022) ISSN: 1875-533X [Electronic] United Arab Emirates
• PMID: 34313197 (Publication Type: Journal Article)
• Copyright: Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Chemical References

• Anti-Inflammatory Agents
• Antiviral Agents
• Biological Products
• Protease Inhibitors

Topics

• Anti-Inflammatory Agents (pharmacology, therapeutic use)
• Antiviral Agents (pharmacology, therapeutic use)
• Biological Products (pharmacology, therapeutic use)
• Drug Discovery
• Humans
• Immunity
• Molecular Docking Simulation
• Protease Inhibitors (pharmacology, therapeutic use)
• SARS-CoV-2
• COVID-19 Drug Treatment