Abstract | BACKGROUND: METHODS: The present study retrospectively recruited patients who were admitted for ACS and underwent coronary angiography at 6 to 24 months after successful DES-based percutaneous coronary intervention (PCI). In addition, we calculated the TyG index with the following formula: Ln(fasting triglyceride [mg/dL] × fasting blood glucose [mg/dL]/2) and divided patients into 3 groups according to the tertile of the TyG index. Most importantly, multivariate logistic regression analysis models were also constructed to assess the association between the TyG index and DES-ISR in patients with ACS. RESULTS: A total of 1574 patients with ACS (58.4 ± 9.4 years, 77.4% male) were included in this study. At the median follow-up time of 12 (9-14) months, the prevalence of DES-ISR increased stepwise with the increasing tertile of the TyG index (11.6% vs 17.3% vs 19.4%, p = 0.002), and the TyG index was also higher in the ISR group than in the non-ISR group (9.00 ± 0.58 vs 8.84 ± 0.61, p < 0.001). In addition, the positive association between the TyG index and the prevalence of DES-ISR was also determined in the fully adjusted model (TyG, per 1-unit increase: OR 1.424, 95% CI 1.116 to 1.818, p = 0.005; tertile of TyG, the OR (95% CI) values for tertile 2 and tertile 3 were 1.454 (1.013 to 2.087) and 1.634 (1.125 to 2.374), respectively, with tertile 1 as a reference). The association was also reflected in most subgroups. Moreover, adding the TyG index to the predictive model for DES-ISR in patients with ACS could contribute to an increase in C-statistics (0.675 vs 0.659, p = 0.010), categorical net reclassification improvement (0.090, p < 0.001), and integrated discrimination improvement (0.004, p = 0.040). CONCLUSION: An elevated TyG index was independently and positively associated with DES-ISR in patients with ACS who underwent PCI. However, the incremental predictive value of the TyG index for DES-ISR was slight. To further confirm our findings, future studies are needed.
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Authors | Yong Zhu, Kesen Liu, Maolin Chen, Yan Liu, Ang Gao, Chengping Hu, Hong Li, Huagang Zhu, Hongya Han, Jianwei Zhang, Yingxin Zhao |
Journal | Cardiovascular diabetology
(Cardiovasc Diabetol)
Vol. 20
Issue 1
Pg. 137
(07 08 2021)
ISSN: 1475-2840 [Electronic] England |
PMID | 34238294
(Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Blood Glucose
- Triglycerides
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Topics |
- Acute Coronary Syndrome
(blood, diagnostic imaging, epidemiology, therapy)
- Aged
- Beijing
(epidemiology)
- Biomarkers
(blood)
- Blood Glucose
(metabolism)
- Coronary Angiography
- Coronary Restenosis
(blood, diagnostic imaging, epidemiology)
- Female
- Humans
- Insulin Resistance
- Male
- Middle Aged
- Percutaneous Coronary Intervention
(adverse effects)
- Predictive Value of Tests
- Prevalence
- Retrospective Studies
- Risk Assessment
- Risk Factors
- Time Factors
- Treatment Outcome
- Triglycerides
(blood)
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