It is of interest to evaluate a single dose of three different
analgesics compared to placebo in patients with symptomatic irreversible
pulpitis. 120 patients were enrolled with severe
pain in this prospective clinical trial. Patients were randomly divided into four groups after shaping and cleaning of root canals. This includes placebo,
piroxicam 20mg,
acetaminophen 325mg with
aceclofenac sodium 100mg and
acetaminophen 650mg. Participants were given a questionnaire to note the
pain scores at various time intervals (6 hrs, 12 hrs, and 24 hrs) along with the respective
tablets in a concealed manner. Data thus collected was analyzed for statistical significance. The severity of
pain decreased in all the three interventional groups compared to the control group (p <0.01) at 6 hours. Zerodol-P and dolonex showed better
pain reduction in comparison to the placebo and dolo 650 group (p <0.05) at 12 and 24 hours. Data shows that both zerodol-P and dolonex groups had similar effects at all time intervals. Thus, a single dose of
analgesic such as Zerodol-P and Dolonex following shaping and cleaning of root canals relieved
pain at all time intervals of the treatment. However, Dolo 650 performed better during the initial 6hrs after completion of the shaping and cleaning of root canals compared to the placebo.