Blood oxygen level-dependent (BOLD) response patterns with thalamic deep brain stimulation in patients with medically refractory epilepsy.

Abstract

OBJECTIVE:

Anterior nucleus of thalamus (ANT) deep brain stimulation (DBS) has shown promise as a treatment for medically refractory epilepsy. To better understand the mechanism of this intervention, we used functional magnetic resonance imaging (fMRI) to map the acute blood oxygen level-dependent (BOLD) response pattern to thalamic DBS in fully implanted patients with epilepsy.

METHODS:

Two patients with epilepsy implanted with bilateral ANT-DBS devices underwent four fMRI acquisitions each, during which active left-sided monopolar stimulation was delivered in a 30-s DBS-ON/OFF cycling paradigm. Each fMRI acquisition featured left-sided stimulation of a different electrode contact to vary the locus of stimulation within the thalamus and to map the brain regions modulated as a function of different contact selection. To determine the extent of peri-electrode stimulation and the engagement of local structures during each fMRI acquisition, volume of tissue activated (VTA) modeling was also performed.

RESULTS:

Marked changes in the pattern of BOLD response were produced with thalamic stimulation, which varied with the locus of the active contact in each patient. BOLD response patterns to stimulation that directly engaged at least 5% of the anterior nuclear group by volume were characterized by changes in the bilateral putamen, thalamus, and posterior cingulate cortex, ipsilateral middle cingulate cortex and precuneus, and contralateral medial prefrontal and anterior cingulate.

SIGNIFICANCE:

The differential BOLD response patterns associated with varying thalamic DBS parameters provide mechanistic insights and highlight the possibilities of fMRI biomarkers of optimizing stimulation in patients with epilepsy.

• Authors: Can Sarica, Kazuaki Yamamoto, Aaron Loh, Gavin J B Elias, Alexandre Boutet, Radhika Madhavan, Jürgen Germann, Ajmal Zemmar, Dave Gwun, Jordy Tasserie, Danielle M Andrade, Mojgan Hodaie, Suneil K Kalia, Richard A Wennberg, Andres M Lozano
• Journal: Epilepsy & behavior : E&B (Epilepsy Behav) Vol. 122 Pg. 108153 (09 2021) ISSN: 1525-5069 [Electronic] United States
• PMID: 34153639 (Publication Type: Journal Article)
• Copyright: Copyright © 2021 Elsevier Inc. All rights reserved.

Chemical References

• Oxygen

Topics

• Anterior Thalamic Nuclei
• Deep Brain Stimulation
• Drug Resistant Epilepsy (diagnostic imaging, therapy)
• Humans
• Magnetic Resonance Imaging
• Oxygen