Abstract | OBJECTIVE: METHODS: We obtained LR-HS from the pyrolysis of rice hulls. Traumatic ulcers were created in the labial fornix incisive inferior of Wistar rats and treated with LR-HS once a day for 3, 5, and 7 days. The control group was treated with sterile water. Each animal was sacrificed after treatment, and its labial fornix incisive inferior tissues were biopsied and immunohistochemically stained to examine FGF, VEGF, PDGF, and COL-1 expression. RESULT: The treatment of traumatic ulcers with LR-HS showed an increase in FGF, VEGF, PDGF, and COL-1 expression. VEGF expression increased under LR-HS treatment compared with the control 7-day treatment groups (p < 0.000). FGF and COL-1 expression increased under LR-HS treatment compared with the control 5- and 7-day treatment groups (p < 0.000). PDGF expression increased after treatment with LR-HS for 3, 5, and 7 days (p < 0.000). CONCLUSION: This study has demonstrated that LR-HS can induce the expression of growth factors during the healing of a traumatic ulcer using immunohistochemical staining. We suggest that LR-HS can be used as a herbal medicine for oral ulcer therapy.
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Authors | Ira Arundina, Indeswati Diyatri, Meircurius D C Surboyo, Elita Monica, Novitasari M Afanda |
Journal | Journal of Taibah University Medical Sciences
(J Taibah Univ Med Sci)
Vol. 16
Issue 3
Pg. 431-439
(Jun 2021)
ISSN: 1658-3612 [Electronic] Saudi Arabia |
PMID | 34140871
(Publication Type: Journal Article)
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Copyright | © 2021 The Authors. |