Abstract | PURPOSE: METHODS: For this purpose, we established a tissue microarray from 208 ovarian cancer patients and performed immunohistochemical analyses of the mentioned proteins. RESULTS: ERRα and ERRγ protein could be detected at different levels in more than 90% of all ovarian cancer tissues, whereas expression of ERRβ was observed in 82.2% of the cases. ERRα was found to positively correlate with ovarian cancer marker CEA (p < 0.005) and ERRγ correlated with ERα (p < 0.001). Univariate survival analyses revealed that ERRα expression did not affect overall (OS) or progression-free survival (PFS) of ovarian cancer patients. In contrast, higher expression of ERRβ in serous ovarian cancers was found to lead to a significantly decreased OS (p < 0.05). The strongest impact on survival was exhibited by ERRγ. Lower expression of this receptor in women with serous ovarian cancers indicated significantly increased OS compared to those with higher levels of ERRγ (p < 0.05). Multivariate survival analyses revealed ERRγ as an independent prognostic marker regarding OS of patients with serous ovarian cancer. CONCLUSION:
|
Authors | Susanne Schüler-Toprak, Florian Weber, Maciej Skrzypczak, Olaf Ortmann, Oliver Treeck |
Journal | Journal of cancer research and clinical oncology
(J Cancer Res Clin Oncol)
Vol. 147
Issue 9
Pg. 2555-2567
(Sep 2021)
ISSN: 1432-1335 [Electronic] Germany |
PMID | 34089362
(Publication Type: Journal Article)
|
Copyright | © 2021. The Author(s). |
Chemical References |
- Biomarkers, Tumor
- ESRRG protein, human
- Receptors, Estrogen
- estrogen receptor-related receptor beta
|
Topics |
- Adenocarcinoma, Clear Cell
(metabolism, mortality, pathology)
- Adenocarcinoma, Mucinous
(metabolism, mortality, pathology)
- Biomarkers, Tumor
(metabolism)
- Cystadenocarcinoma, Serous
(metabolism, mortality, pathology)
- Endometrial Neoplasms
(metabolism, mortality, pathology)
- Female
- Follow-Up Studies
- Humans
- Ovarian Neoplasms
(metabolism, mortality, pathology)
- Prognosis
- Receptors, Estrogen
(metabolism)
- Retrospective Studies
- Survival Rate
- ERRalpha Estrogen-Related Receptor
|