Abstract | ETHNOPHARMACOLOGICAL RELEVANCE: AIM OF THIS STUDY: This study aimed to clearly define the efficacy and underlying mechanism of SMY and its active components in protecting against atherosclerosis. MATERIALS AND METHODS: The pharmacological effects of SMY and its components were evaluated upon a mouse hypercholesteremia model induced by a high cholesterol diet (HCD) for 12 weeks and Apoe-/- mice, a mouse atherosclerosis model. Pathological indicators including serum cholesterol levels, cytokines and histological changes in aortic root plaques were assessed. Untargeted metabolomic, untargeted lipidomic and targeted lipidomic changing profiles were investigated to clarify pharmacological mechanisms. RESULTS: CONCLUSIONS:
|
Authors | Yun Wang, Jiawei Wu, Jiaying Zhu, Chujie Ding, Wanfeng Xu, Haiping Hao, Jun Zhang, Guangji Wang, Lijuan Cao |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 277
Pg. 114223
(Sep 15 2021)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 34044080
(Publication Type: Journal Article)
|
Copyright | Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved. |
Chemical References |
- Apolipoproteins E
- Cholesterol, Dietary
- Cytokines
- Drug Combinations
- Drugs, Chinese Herbal
- Ginsenosides
- Lysophosphatidylcholines
- fructus schizandrae, radix ginseng, radix ophiopogonis drug combination
- Cholesterol
|
Topics |
- Animals
- Apolipoproteins E
(genetics)
- Atherosclerosis
(genetics, prevention & control)
- Cholesterol
(blood)
- Cholesterol, Dietary
- Cytokines
(blood)
- Disease Models, Animal
- Drug Combinations
- Drugs, Chinese Herbal
(pharmacology)
- Ginsenosides
(isolation & purification, pharmacology)
- Lysophosphatidylcholines
(blood)
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
|