MicroRNA-543-3p down-regulates inflammation and inhibits periodontitis through KLF6.

Abstract

MicroRNA-543-3p (miR-543-3p) has been reported to be involved in many human disease's progression, but its role in inflammation is still unclear. After bacterial infection, innate immune cells are activated to trigger inflammation by recognizing lipopolysaccharide (LPS) on the bacterial outer membrane. In our research, it showed that miR-543-3p was down-regulated in LPS-treated periodontal ligament cells (PDLCs). And it mediated the apoptosis of PDLC induced by LPS, which may be involved in periodontitis development. Besides, up-regulation of miR-543-3p alleviated the inflammatory damage induced by LPS. Furthermore, our research demonstrated Kruppel-like factor 6 (KLF6) served as a direct downstream target of miR-543-3p to play a vital role in periodontitis. Simply put, these findings suggest that miR-543-3p could down-regulate inflammation and inhibit periodontitis by targeting KLF6, and it provides a new insight into the molecular mechanism of periodontitis, which may be helpful for the early diagnosis and treatment of this disease.

• Authors: Wei Li, Junwei Wang, Wenjing Hao, Cuifang Yu
• Journal: Bioscience reports (Biosci Rep) Vol. 41 Issue 5 (05 28 2021) ISSN: 1573-4935 [Electronic] England
• PMID: 33955459 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2021 The Author(s).

Chemical References

• KLF6 protein, human
• Kruppel-Like Factor 6
• MIRN543 microRNA, human
• MicroRNAs

Topics

• Apoptosis
• Cells, Cultured
• Down-Regulation
• Humans
• Kruppel-Like Factor 6 (genetics, metabolism)
• MicroRNAs (genetics, metabolism)
• Periodontal Ligament (cytology, metabolism)
• Periodontitis (genetics, metabolism)