Abstract |
Hemostasis is of great significance regardless of the smooth operation or postoperative recovery. Therefore, it is urgent to develop a hemostatic material with excellent biodegradability and biocompatibility. It is well known that both carboxymethyl chitosan and hyaluronic acid with biodegradability and biocompatibility have wound healing promoting property. Here, a degradable chitosan-based hydrogel was prepared based on carboxymethyl chitosan and cross-linked by oxidized hyaluronic acid. The hemostatic performance of the hydrogel in rat liver resection injury was evaluated which results showed that the hydrogel exhibited comparable hemostatic properties compared with Fibrin Sealant. In addition, the hydrogel proved to be rapidly absorbed by the body without significant accumulation in vivo, demonstrating good biodegradability and biocompatibility. The overall results suggested the hydrogel will be a promising hemostatic hydrogel for controlling bleeding.
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Authors | Lixin Xia, Shuo Wang, Zhiwen Jiang, Jinhua Chi, Shuqin Yu, Hongjian Li, Yijie Zhang, Lihua Li, Changren Zhou, Wanshun Liu, Baoqin Han |
Journal | Carbohydrate polymers
(Carbohydr Polym)
Vol. 264
Pg. 117965
(Jul 15 2021)
ISSN: 1879-1344 [Electronic] England |
PMID | 33910708
(Publication Type: Journal Article)
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Copyright | Copyright © 2021 Elsevier Ltd. All rights reserved. |
Chemical References |
- Biocompatible Materials
- Cross-Linking Reagents
- Hemostatics
- Hydrogels
- carboxymethyl-chitosan
- Hyaluronic Acid
- Chitosan
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Topics |
- Animals
- Biocompatible Materials
(chemistry, pharmacokinetics)
- Chitosan
(analogs & derivatives, chemistry, metabolism, pharmacokinetics)
- Cross-Linking Reagents
(chemistry)
- Female
- Hemostasis
- Hemostatics
(chemistry, metabolism, pharmacokinetics)
- Hyaluronic Acid
(chemistry, metabolism, pharmacokinetics)
- Hydrogels
(chemistry, metabolism, pharmacokinetics)
- Liver
(metabolism)
- Male
- Oxidation-Reduction
- Rats
- Rats, Sprague-Dawley
- Tissue Distribution
- Wound Healing
(drug effects)
- Wounds and Injuries
(metabolism, therapy)
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