HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Hemostatic performance of chitosan-based hydrogel and its study on biodistribution and biodegradability in rats.

Abstract
Hemostasis is of great significance regardless of the smooth operation or postoperative recovery. Therefore, it is urgent to develop a hemostatic material with excellent biodegradability and biocompatibility. It is well known that both carboxymethyl chitosan and hyaluronic acid with biodegradability and biocompatibility have wound healing promoting property. Here, a degradable chitosan-based hydrogel was prepared based on carboxymethyl chitosan and cross-linked by oxidized hyaluronic acid. The hemostatic performance of the hydrogel in rat liver resection injury was evaluated which results showed that the hydrogel exhibited comparable hemostatic properties compared with Fibrin Sealant. In addition, the hydrogel proved to be rapidly absorbed by the body without significant accumulation in vivo, demonstrating good biodegradability and biocompatibility. The overall results suggested the hydrogel will be a promising hemostatic hydrogel for controlling bleeding.
AuthorsLixin Xia, Shuo Wang, Zhiwen Jiang, Jinhua Chi, Shuqin Yu, Hongjian Li, Yijie Zhang, Lihua Li, Changren Zhou, Wanshun Liu, Baoqin Han
JournalCarbohydrate polymers (Carbohydr Polym) Vol. 264 Pg. 117965 (Jul 15 2021) ISSN: 1879-1344 [Electronic] England
PMID33910708 (Publication Type: Journal Article)
CopyrightCopyright © 2021 Elsevier Ltd. All rights reserved.
Chemical References
  • Biocompatible Materials
  • Cross-Linking Reagents
  • Hemostatics
  • Hydrogels
  • carboxymethyl-chitosan
  • Hyaluronic Acid
  • Chitosan
Topics
  • Animals
  • Biocompatible Materials (chemistry, pharmacokinetics)
  • Chitosan (analogs & derivatives, chemistry, metabolism, pharmacokinetics)
  • Cross-Linking Reagents (chemistry)
  • Female
  • Hemostasis
  • Hemostatics (chemistry, metabolism, pharmacokinetics)
  • Hyaluronic Acid (chemistry, metabolism, pharmacokinetics)
  • Hydrogels (chemistry, metabolism, pharmacokinetics)
  • Liver (metabolism)
  • Male
  • Oxidation-Reduction
  • Rats
  • Rats, Sprague-Dawley
  • Tissue Distribution
  • Wound Healing (drug effects)
  • Wounds and Injuries (metabolism, therapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: