Abstract | BACKGROUND: METHODS: Infants less than 6 months old were recruited during hospitalization due to bronchiolitis. In all, 166 children were prospectively followed up to age of 1.5, 6, and 11 years. Clinical data on viral etiology and severity markers, and further post- bronchiolitis asthma and lung function outcomes were compared with genetic differences in two single- nucleotide point mutations rs116938768 and rs5743854 in the toll-interacting protein gene. RESULTS: Toll-interacting protein rs116938768 or rs5743854 did not show significant associations with severity markers or viral etiology of bronchiolitis. Follow-up data on current asthma or lung function at 6 or 11 years of age after bronchiolitis were not associated with the investigated mutations. CONCLUSION:
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Authors | Sari Törmänen, Johanna Teräsjärvi, Kirsi Nuolivirta, Qiushui He, Matti Korppi, Eero Lauhkonen |
Journal | Pediatrics international : official journal of the Japan Pediatric Society
(Pediatr Int)
Vol. 63
Issue 9
Pg. 1103-1107
(Sep 2021)
ISSN: 1442-200X [Electronic] Australia |
PMID | 33877723
(Publication Type: Journal Article)
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Copyright | © 2021 The Authors. Pediatrics International published by John Wiley & Sons Australia, Ltd on behalf of Japan Pediatric Society. |
Chemical References |
- Intracellular Signaling Peptides and Proteins
- TOLLIP protein, human
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Topics |
- Asthma
(genetics)
- Bronchiolitis, Viral
(genetics)
- Child
- Child, Preschool
- Hospitalization
- Humans
- Infant
- Intracellular Signaling Peptides and Proteins
(genetics)
- Polymorphism, Genetic
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