Deep Brain Stimulation Initiative: Toward Innovative Technology, New Disease Indications, and Approaches to Current and Future Clinical Challenges in Neuromodulation Therapy.
Abstract |
Deep brain stimulation (DBS) is one of the most important clinical therapies for neurological disorders. DBS also has great potential to become a great tool for clinical neuroscience research. Recently, the National Engineering Laboratory for Neuromodulation at Tsinghua University held an international Deep Brain Stimulation Initiative workshop to discuss the cutting-edge technological achievements and clinical applications of DBS. We specifically addressed new clinical approaches and challenges in DBS for movement disorders ( Parkinson's disease and dystonia), clinical application toward neurorehabilitation for stroke, and the progress and challenges toward DBS for neuropsychiatric disorders. This review highlighted key developments in (1) neuroimaging, with advancements in 3-Tesla magnetic resonance imaging DBS compatibility for exploration of brain network mechanisms; (2) novel DBS recording capabilities for uncovering disease pathophysiology; and (3) overcoming global healthcare burdens with online-based DBS programming technology for connecting patient communities. The successful event marks a milestone for global collaborative opportunities in clinical development of neuromodulation to treat major neurological disorders.
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Authors | Yanan Sui, Ye Tian, Wai Kin Daniel Ko, Zhiyan Wang, Fumin Jia, Andreas Horn, Dirk De Ridder, Ki Sueng Choi, Ausaf A Bari, Shouyan Wang, Clement Hamani, Kenneth B Baker, Andre G Machado, Tipu Z Aziz, Erich Talamoni Fonoff, Andrea A Kühn, Hagai Bergman, Terence Sanger, Hesheng Liu, Suzanne N Haber, Luming Li |
Journal | Frontiers in neurology
(Front Neurol)
Vol. 11
Pg. 597451
( 2020)
ISSN: 1664-2295 [Print] Switzerland |
PMID | 33584498
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2021 Sui, Tian, Ko, Wang, Jia, Horn, De Ridder, Choi, Bari, Wang, Hamani, Baker, Machado, Aziz, Fonoff, Kühn, Bergman, Sanger, Liu, Haber and Li. |
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