Abstract | PURPOSE: METHODS: RESULTS: Resistance to thyroid hormone beta (RTHβ) patients exhibited higher LDL-C (P = 0.008) and TG (P = 0.002) and lower HDL-C concentrations (P = 0.015 × 10-2) than control subjects, with LDL-C being higher than in thyrotoxic patients with comparable hyperthyroxinemia. Proprotein convertase subtilisin/kexin 9 (P = 0.002) and apolipoprotein B (P = 0.0009) levels were reduced in thyrotoxic patients but not lower in RTHβ patients or control subjects. Intrahepatic lipid (P = 0.02 × 10-4), IMCL (P = 0.002), HOMA-IR (P = 0.01 × 10-2), and NEFA (P = 0.04 × 10-6) were significantly higher in RTHβ patients than control subjects. Flow-mediated dilatation was increased (P = 0.04) but cIMT (P = 0.71), PWV P = 0.81), and AIx (P = 0.95) were unaltered in RTHβ patients. CONCLUSIONS: We have documented mixed dyslipidemia with hepatic and IMCL accumulation in RTHβ, suggesting that surveillance for these metabolic abnormalities is warranted. How they combine with enhanced endothelial function and unaltered vessel wall thickness and compliance to determine overall cardiometabolic risk in this disorder remains to be defined.
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Authors | Carla Moran, Carmel M McEniery, Nadia Schoenmakers, Catherine Mitchell, Alison Sleigh, Laura Watson, Greta Lyons, Keith Burling, Peter Barker, Krishna Chatterjee |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 106
Issue 5
Pg. e2005-e2014
(04 23 2021)
ISSN: 1945-7197 [Electronic] United States |
PMID | 33524107
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. |
Chemical References |
- Biomarkers
- Lipids
- Thyroid Hormone Receptors beta
- Thyroid Hormones
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Topics |
- Adult
- Biomarkers
(analysis)
- Carotid Intima-Media Thickness
- Case-Control Studies
- Dyslipidemias
(epidemiology, metabolism, pathology)
- Female
- Follow-Up Studies
- Humans
- Hypercholesterolemia
(epidemiology, metabolism, pathology)
- Insulin Resistance
- Lipids
(analysis)
- Male
- Mutation
- Prognosis
- Thyroid Hormone Receptors beta
(genetics)
- Thyroid Hormones
(metabolism)
- United Kingdom
(epidemiology)
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