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Multi-organ proteomic landscape of COVID-19 autopsies.

Abstract
The molecular pathology of multi-organ injuries in COVID-19 patients remains unclear, preventing effective therapeutics development. Here, we report a proteomic analysis of 144 autopsy samples from seven organs in 19 COVID-19 patients. We quantified 11,394 proteins in these samples, in which 5,336 were perturbed in the COVID-19 patients compared to controls. Our data showed that cathepsin L1, rather than ACE2, was significantly upregulated in the lung from the COVID-19 patients. Systemic hyperinflammation and dysregulation of glucose and fatty acid metabolism were detected in multiple organs. We also observed dysregulation of key factors involved in hypoxia, angiogenesis, blood coagulation, and fibrosis in multiple organs from the COVID-19 patients. Evidence for testicular injuries includes reduced Leydig cells, suppressed cholesterol biosynthesis, and sperm mobility. In summary, this study depicts a multi-organ proteomic landscape of COVID-19 autopsies that furthers our understanding of the biological basis of COVID-19 pathology.
AuthorsXiu Nie, Liujia Qian, Rui Sun, Bo Huang, Xiaochuan Dong, Qi Xiao, Qiushi Zhang, Tian Lu, Liang Yue, Shuo Chen, Xiang Li, Yaoting Sun, Lu Li, Luang Xu, Yan Li, Ming Yang, Zhangzhi Xue, Shuang Liang, Xuan Ding, Chunhui Yuan, Li Peng, Wei Liu, Xiao Yi, Mengge Lyu, Guixiang Xiao, Xia Xu, Weigang Ge, Jiale He, Jun Fan, Junhua Wu, Meng Luo, Xiaona Chang, Huaxiong Pan, Xue Cai, Junjie Zhou, Jing Yu, Huanhuan Gao, Mingxing Xie, Sihua Wang, Guan Ruan, Hao Chen, Hua Su, Heng Mei, Danju Luo, Dashi Zhao, Fei Xu, Yan Li, Yi Zhu, Jiahong Xia, Yu Hu, Tiannan Guo
JournalCell (Cell) Vol. 184 Issue 3 Pg. 775-791.e14 (02 04 2021) ISSN: 1097-4172 [Electronic] United States
PMID33503446 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2021 Elsevier Inc. All rights reserved.
Chemical References
  • Proteome
Topics
  • Autopsy
  • COVID-19 (metabolism, pathology, therapy)
  • Female
  • Gene Expression Regulation
  • Humans
  • Male
  • Organ Specificity
  • Proteome (biosynthesis)
  • Proteomics
  • SARS-CoV-2 (metabolism)

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