Cortisol-Producing Adrenal Adenomas With Intense Activity on 68Ga-Pentixafor PET/CT.

Abstract

ABSTRACT:

CXC chemokine receptor type 4 as a G-protein-coupled receptor has been confirmed to be highly expressed in functional adrenocortical adenomas. 68Ga-pentixafor, a CXC chemokine receptor type 4-specific ligand, has been reported as a promising tracer to evaluate functional nature of adrenal adenomas. We report intense 68Ga-pentixafor activity of cortisol-producing adrenal adenomas in 2 patients with adrenocorticotropic hormone-independent Cushing syndrome.

• Authors: Jie Ding, Anli Tong, YuShi Zhang, Hui Zhang, Li Huo
• Journal: Clinical nuclear medicine (Clin Nucl Med) Vol. 46 Issue 4 Pg. 350-352 (04 01 2021) ISSN: 1536-0229 [Electronic] United States
• PMID: 33492858 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.

Chemical References

• 68Ga-pentixafor
• Coordination Complexes
• Peptides, Cyclic

Topics

• Adrenal Cortex Neoplasms (diagnostic imaging, metabolism)
• Adrenocortical Adenoma (diagnostic imaging, metabolism)
• Coordination Complexes
• Female
• Humans
• Middle Aged
• Peptides, Cyclic
• Positron Emission Tomography Computed Tomography