Abstract | BACKGROUND: METHODS: Thirty patients were enrolled and orally administered 2.5 g keishibukuryogan three times daily for 12 weeks. The frequency, strength, and duration of hot flashes were self-evaluated by the patients in a diary every 4 weeks. All patients also completed a questionnaire to determine their aging male symptoms (AMS) scale score and underwent blood biochemical testing. RESULTS: Twenty-five patients completed the 12-week treatment. Hot flash strength significantly improved 4, 8, and 12 weeks after treatment. Their frequency was significantly reduced at the 8-week visit, and duration was significantly shorter after the 8-week visit. In addition, the score of the AMS somatic subscale was improved at the 8- and 12-week visits. Among the somatic items, questions 3 (excessive sweating) and 5 (increased need for sleep) were significantly improved. Obesity, radiation, and a longer duration of PC were predictive factors for treatment response. Prostate specific antigen and total testosterone levels were unchanged, and no patients had severe adverse effects. CONCLUSIONS:
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Authors | Kazuyoshi Shigehara, Kouji Izumi, Kazufumi Nakashima, Shohei Kawaguchi, Takahiro Nohara, Yoshifumi Kadono, Atsushi Mizokami |
Journal | Translational andrology and urology
(Transl Androl Urol)
Vol. 9
Issue 6
Pg. 2533-2540
(Dec 2020)
ISSN: 2223-4691 [Print] China |
PMID | 33457227
(Publication Type: Journal Article)
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Copyright | 2020 Translational Andrology and Urology. All rights reserved. |