Treatment of Severe COVID-19 with Convalescent Plasma in the Bronx, NYC.

Abstract

Convalescent plasma with severe acute respiratory disease coronavirus 2 (SARS-CoV-2) antibodies (CCP) may hold promise as treatment for Coronavirus Disease 2019 (COVID-19). We compared the mortality and clinical outcome of patients with COVID-19 who received 200mL of CCP with a Spike protein IgG titer ≥1:2,430 (median 1:47,385) within 72 hours of admission to propensity score-matched controls cared for at a medical center in the Bronx, between April 13 to May 4, 2020. Matching criteria for controls were age, sex, body mass index, race, ethnicity, comorbidities, week of admission, oxygen requirement, D-dimer, lymphocyte counts, corticosteroids, and anticoagulation use. There was no difference in mortality or oxygenation between CCP recipients and controls at day 28. When stratified by age, compared to matched controls, CCP recipients <65 years had 4-fold lower mortality and 4-fold lower deterioration in oxygenation or mortality at day 28. For CCP recipients, pre-transfusion Spike protein IgG, IgM and IgA titers were associated with mortality at day 28 in univariate analyses. No adverse effects of CCP were observed. Our results suggest CCP may be beneficial for hospitalized patients <65 years, but data from controlled trials is needed to validate this finding and establish the effect of ageing on CCP efficacy.

• Authors: Hyun Ah Yoon, Rachel Bartash, Inessa Gendlina, Johanna Rivera, Antonio Nakouzi, Robert H Bortz 3rd, Ariel S Wirchnianski, Monika Paroder, Karen Fehn, Leana Serrano-Rahman, Rachelle Babb, Uzma N Sarwar, Denise Haslwanter, Ethan Laudermilch, Catalina Florez, M Eugenia Dieterle, Rohit K Jangra, J Maximilian Fels, Karen Tong, Margarette C Mariano, Olivia Vergnolle, George I Georgiev, Natalia G Herrera, Ryan J Malonis, Jose A Quiroz, Nicholas C Morano, Gregory J Krause, Joseph M Sweeney, Kelsie Cowman, Stephanie Allen, Jayabhargav Annam, Ariella Applebaum, Daniel Barboto, Ahmed Khokhar, Brianna J Lally, Audrey Lee, Max Lee, Avinash Malaviya, Reise Sample, Xiuyi A Yang, Yang Li, Rafael Ruiz, Raja Thota, Jason Barnhill, Doctor Y Goldstein, Joan Uehlinger, Scott J Garforth, Steven C Almo, Jonathan R Lai, Morayma Reyes Gil, Amy S Fox, Kartik Chandran, Tao Wang, Johanna P Daily, Liise-Anne Pirofski
• Journal: medRxiv : the preprint server for health sciences (medRxiv) (Dec 04 2020) United States
• PMID: 33300012 (Publication Type: Preprint)