Abstract |
Systemic inflammation will cause an imbalance in the steady state of the gut-brain axis. Phosphatidylcholine (PC) is a phospholipid found in egg yolk that has anti-inflammatory and antioxidant properties. The present research proved that PC supplementation (60 mg/kg body weight) for 35 days prevented inflammatory responses and behavioral disturbances in lipopolysaccharide (LPS)-induced mice. PC could regulate the expression of neurotrophic factors and synaptic proteins, which effectively alleviated the nerve damage and synaptic dysfunction caused by LPS. In addition, PC supplementation ameliorated gut barrier damage, altered gut genes, and improved gut health by modulating the cell adhesion molecule (CAM) pathway. Furthermore, PC remodeled the gut microbiome structure in the mice of the LPS group by increasing the relative abundance of Rikenellaceae and Lachnospiraceae. PC also increased short-chain fatty acid (SCFA) production in LPS-induced mice, which in turn ameliorated brain inflammatory responses. In conclusion, PC supplementation may be a nutritional strategy for the prevention of systemic inflammation via the gut-brain axis.
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Authors | Wen Tan, Qinjun Zhang, Zhijian Dong, Yubin Yan, Yukun Fu, Xuebo Liu, Beita Zhao, Xiang Duan |
Journal | Journal of agricultural and food chemistry
(J Agric Food Chem)
Vol. 68
Issue 50
Pg. 14884-14895
(Dec 16 2020)
ISSN: 1520-5118 [Electronic] United States |
PMID | 33289390
(Publication Type: Journal Article)
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Chemical References |
- Anti-Inflammatory Agents
- Cell Adhesion Molecules
- Fatty Acids, Volatile
- Lipopolysaccharides
- Phosphatidylcholines
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Topics |
- Animals
- Anti-Inflammatory Agents
(administration & dosage)
- Bacteria
(classification, genetics, isolation & purification)
- Brain
(drug effects, metabolism)
- Cell Adhesion Molecules
(genetics, metabolism)
- Cognitive Dysfunction
(drug therapy, genetics, metabolism, microbiology)
- Fatty Acids, Volatile
- Gastrointestinal Microbiome
(drug effects)
- Humans
- Inflammation
(drug therapy, etiology, genetics, metabolism)
- Lipopolysaccharides
(adverse effects)
- Male
- Mice
- Mice, Inbred C57BL
- Phosphatidylcholines
(administration & dosage)
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