A comparison of two intravesical bladder instillations for interstitial cystitis/bladder pain syndrome.

Abstract

OBJECTIVE:

Bladder pain syndrome (BPS) is a chronic pain condition associated with injury to the glycosoaminoglycan (GAG) layer. We aimed to prospectively evaluate iAluRil® with multi-centre tertiary urogynaecology collaboration. We hypothesised that iAluRil® (a GAG therapy) would demonstrate equivalent symptom, pain and QOL scores compared to DMSO controls.

STUDY DESIGN:

iAluRil® was administered for 7 instillations over 3 months in 34 women over 6 sites. 18 historical DMSO controls were matched 2:1. At baseline and 3 months post treatment validated questionnaires were collected.

RESULTS:

Both iAluRil® and DMSO were associated with statistically significant improvements in IC/BPS specific questionnaire scores. iAluRil® showed statistically significant improvements in pain, symptoms, and QOL. 45 % of iAluRil® recipients had a greater than 50 % reduction in pain score as represented by the VAS. DMSO was also effective in improving measures of IC/BPS with statistically significant decreases in ICSI and ICPI. There was no statistically significant difference in the size of the effect between DMSO and IAluRil®.

CONCLUSIONS:

iAluRil® is well tolerated and associated with significant improvements in pain and symptom scores. Almost half of refractory BPS will have a 50 % decrease in pain score at three months post treatment. This effect size is similar to DMSO.

• Authors: J Keane, N Young, J Goh, M Atherton, J Yin, K Moore, P Hall, P Higgs, A Leitch, J Lee, A Rosamilia
• Journal: European journal of obstetrics, gynecology, and reproductive biology (Eur J Obstet Gynecol Reprod Biol) Vol. 256 Pg. 230-234 (Jan 2021) ISSN: 1872-7654 [Electronic] Ireland
• PMID: 33248378 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 Elsevier B.V. All rights reserved.

Topics

• Administration, Intravesical
• Cystitis, Interstitial (drug therapy)
• Female
• Humans
• Pain (drug therapy)
• Quality of Life
• Treatment Outcome