Relationships between diuretic-related hyperuricemia and cardiovascular events: data from the URic acid Right for heArt Health study.

Abstract

OBJECTIVE:

Although the relationship between hyperuricemia and cardiovascular events has been extensively examined, data on the role of diuretic-related hyperuricemia are still scanty. The present study was designed to collect information on the relationship between diuretic-related hyperuricemia and cardiovascular events.

METHODS:

The URic acid Right for heArt Health (URRAH) study is a nationwide, multicentre, observational cohort study involving data on individuals recruited from all the Italy territory under the patronage of the Italian Society of Hypertension with an average follow-up period of 122.3 ± 66.9 months. Patients were classified into four groups according to the diuretic use (yes vs. no) and serum uric acid (SUA) levels (higher vs. lower than the median value of 4.8 mg/dl). All-cause death, cardiovascular deaths and first cardiovascular event were considered as outcomes.

RESULTS:

Seventeen thousand, seven hundred and forty-seven individuals were included in the analysis. Mean age was 57.1 ± 15.2 years, men were 45.3% and SBP and DBP amounted to 144.1 ± 24.6 and 85.2 ± 13.2 mmHg. 17.2% of individuals take diuretics of whom 58% had SUA higher than median value. Patients with hyperuricemia without diuretic use served as reference group. In multivariate adjusted analysis (sex, age, SBP, BMI, glucose, total cholesterol, and glomerular filtration rate) individuals with hyperuricemia and diuretic use exhibit a similar risk for the three outcomes as compared with the reference group.

CONCLUSION:

Our study showed that diuretic-related hyperuricemia carry a similar risk of cardiovascular events and all-cause mortality when compared with individuals that present hyperuricemia in absence of diuretic therapy.

• Authors: Alessandro Maloberti, Michele Bombelli, Rita Facchetti, Carlo Maria Barbagallo, Bruno Bernardino, Enrico Agabiti Rosei, Edoardo Casiglia, Arrigo Francesco Giuseppe Cicero, Massimo Cirillo, Pietro Cirillo, Giovambattista Desideri, Lanfranco D'elia, Raffaella Dell'Oro, Claudio Ferri, Ferruccio Galletti, Cristina Giannattasio, Gesualdo Loreto, Guido Iaccarino, Luciano Lippa, Francesca Mallamaci, Stefano Masi, Alberto Mazza, Maria Lorenza Muiesan, Pietro Nazzaro, Gianfranco Parati, Paolo Palatini, Paolo Pauletto, Roberto Pontremoli, Fosca Quarti-Trevano, Marcello Rattazzi, Giulia Rivasi, Massimo Salvetti, Valerie Tikhonoff, Giuliano Tocci, Andrea Ungar, Paolo Verdecchia, Francesca Viazzi, Massimo Volpe, Agostino Virdis, Guido Grassi, Claudio Borghi, Working Group on Uric Acid, Cardiovascular Risk of the Italian Society of Hypertension (SIIA)
• Journal: Journal of hypertension (J Hypertens) Vol. 39 Issue 2 Pg. 333-340 (02 01 2021) ISSN: 1473-5598 [Electronic] Netherlands
• PMID: 33239553 (Publication Type: Journal Article, Observational Study)
• Copyright: Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.

Chemical References

• Diuretics
• Uric Acid

Topics

• Diuretics (adverse effects)
• Humans
• Hypertension
• Hyperuricemia (chemically induced, complications)
• Male
• Middle Aged
• Risk Factors
• Uric Acid