Abstract | BACKGROUND: OBJECTIVE: We analyzed apoB algorithm defined HLP3 at different TG levels to optimize the TG cutoff for the algorithm. METHODS: 128,485 UC lipid profiles in the Very Large Database of Lipids (VLDbL) were analyzed. RLP-C was assessed at TG ≥ 133 mg/dL, ≥175 mg/dL, ≥200 mg/dL, and ≥ 250 mg/dL. Sensitivity (Sn), specificity (Sp), positive predictive value (PPV), negative predictive value (NPV), and prevalence adjusted and bias-adjusted kappa (PABAK) were calculated against UC Criterion (VLDL-C/TG ≥ 0.25) for HLP3. RESULTS: The median age (IQR) was 57 years (46-68). 45% were men, 20.1% had diabetes, and 25.5% had hypertension. The median RLP-C level for the TG cutoffs (mg/dL) of ≥ 133, ≥ 175, ≥ 200, and ≥ 250 were 34, 43, 50, and 62 mg/dL, respectively, compared to 67 mg/dL in UC defined HLP3. TG ≥ 133 mg/dL yielded optimal results (Sn 29.5%, Sp 98.5%, PABAK 0.96, PPV 13.6%, NPV 99.4%). CONCLUSION: TG ≥ 133 mg/dL allows for high sensitivity in screening for HLP3. Higher TG cutoffs may identify more severe HLP3 phenotypes, but with a large loss in sensitivity for HLP3.
|
Authors | Bibin Varghese, Jihwan Park, Erin Chew, Aparna Sajja, Adam Brownstein, Vincent A Pallazola, Vasanth Sathiyakumar, Steven R Jones, Allan D Sniderman, Seth S Martin |
Journal | Journal of clinical lipidology
(J Clin Lipidol)
2021 Jan-Feb
Vol. 15
Issue 1
Pg. 104-115.e9
ISSN: 1933-2874 [Print] United States |
PMID | 33189625
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2020 National Lipid Association. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Lipoproteins
- Triglycerides
|
Topics |
- Female
- Humans
- Hypertriglyceridemia
- Lipoproteins
- Male
- Middle Aged
- Triglycerides
|