Abstract | INTRODUCTION: METHODS: In this case-control study, 16 patients who developed pulmonary edema during ritodrine infusion [case], and 16 pregnant women who were treated with ritodrine and did not develop pulmonary edema [control] were included. The control pregnant women were selected after matching for plurality and gestational age at the time of tocolytic use. Maternal blood was collected during admission for tocolytic treatment, and whole exome sequencing was performed with the stored blood samples. RESULTS: Gene-wise variant burden (GVB) analysis resulted in a total of 71 candidate genes by comparing the cumulative effects of multiple coding variants for 19729 protein-coding genes between the patients with pulmonary edema and the matched controls. Subsequent data analysis selected only the statistically significant and deleterious variants compatible with ritodrine-induced pulmonary edema. Two final candidate variants in CPT2 and ADRA1A were confirmed by Sanger sequencing. CONCLUSIONS:
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Authors | Seung Mi Lee, Yoomi Park, Young Ju Kim, Han-Sung Hwang, Heewon Seo, Byung-Joo Min, Kye Hwa Lee, So Yeon Kim, Young Mi Jung, Suehyun Lee, Chan-Wook Park, Ju Han Kim, Joong Shin Park |
Journal | PloS one
(PLoS One)
Vol. 15
Issue 11
Pg. e0241215
( 2020)
ISSN: 1932-6203 [Electronic] United States |
PMID | 33166306
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Tocolytic Agents
- Ritodrine
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Topics |
- Adult
- Case-Control Studies
- Female
- Genetic Variation
(genetics)
- Humans
- Myometrium
(drug effects)
- Obstetric Labor, Premature
(drug therapy, genetics)
- Pregnancy
- Pulmonary Edema
(chemically induced, genetics)
- Ritodrine
(adverse effects)
- Tocolytic Agents
(adverse effects)
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