Nociceptive signaling mediated by P2X3, P2X4 and P2X7 receptors.

Abstract

Chronic pain is a debilitating condition that often occurs following peripheral tissue inflammation and nerve injury. This pain, especially neuropathic pain, is a significant clinical problem because of the ineffectiveness of clinically available drugs. Since Burnstock proposed new roles of nucleotides as neurotransmitters, the roles of extracellular ATP and P2 receptors (P2Rs) in pain signaling have been extensively studied, and ATP-P2R signaling has subsequently received much attention as it can provide clues toward elucidating the mechanisms underlying chronic pain and serve as a potential therapeutic target. This review summarizes the literature regarding the role of ATP signaling via P2X3Rs (as well as P2X2/3Rs) in primary afferent neurons and via P2X4Rs and P2X7Rs in spinal cord microglia in chronic pain, and discusses their respective therapeutic potentials.

• Authors: Kazuhide Inoue, Makoto Tsuda
• Journal: Biochemical pharmacology (Biochem Pharmacol) Vol. 187 Pg. 114309 (05 2021) ISSN: 1873-2968 [Electronic] England
• PMID: 33130129 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2020 Elsevier Inc. All rights reserved.

Chemical References

• Purinergic P2X Receptor Agonists
• Purinergic P2X Receptor Antagonists
• Receptors, Purinergic P2X3
• Receptors, Purinergic P2X4
• Receptors, Purinergic P2X7
• Adenosine Triphosphate

Topics

• Adenosine Triphosphate (metabolism)
• Animals
• Chronic Pain (drug therapy, metabolism)
• Humans
• Nociception (drug effects, physiology)
• Purinergic P2X Receptor Agonists (administration & dosage)
• Purinergic P2X Receptor Antagonists (administration & dosage)
• Receptors, Purinergic P2X3 (metabolism)
• Receptors, Purinergic P2X4 (metabolism)
• Receptors, Purinergic P2X7 (metabolism)
• Sensory Receptor Cells (drug effects, metabolism)
• Signal Transduction (drug effects, physiology)
• Spinal Cord (drug effects, metabolism)