Visceral adiposity is associated with the discrepancy between glycated albumin and HbA1c in type 2 diabetes.

Abstract

AIM:

We investigated the association of visceral adiposity with glycated albumin (GA) as well as GA/hemoglobin A1c (HbA1c) in type 2 diabetes.

METHODS:

One hundred twenty-three patients (68 males, 55 females) with type 2 diabetes were enrolled in this cross-sectional study. Visceral fat area (VFA) was determined using an abdominal dual bioelectrical impedance analysis (dual BIA) instrument. The relationship of VFA with GA and GA/HbA1c was analyzed.

RESULTS:

Simple regression analysis showed that BMI was inversely correlated with GA as well as GA/HbA1c, but not with HbA1c, while VFA had a significant correlation with GA and GA/HbA1c. Furthermore, multiple regression analysis revealed VFA as an independent contributor to GA/HbA1c. These results suggest that visceral adiposity is a primary factor associated with GA and HbA1c level discrepancy in patients with type 2 diabetes.

CONCLUSIONS:

GA is a useful indicator for glycemic control, while visceral obesity should also be taken into consideration in type 2 diabetes cases.

• Authors: Saori Maruo, Koka Motoyama, Tomoe Hirota, Yoshinori Kakutani, Yuko Yamazaki, Tomoaki Morioka, Katsuhito Mori, Shinya Fukumoto, Atsushi Shioi, Tetsuo Shoji, Masaaki Inaba, Masanori Emoto
• Journal: Diabetology international (Diabetol Int) Vol. 11 Issue 4 Pg. 368-375 (Oct 2020) ISSN: 2190-1678 [Print] Japan
• PMID: 33088644 (Publication Type: Journal Article)
• Copyright: © The Japan Diabetes Society 2020.