Abstract | BACKGROUND: METHODOLOGY: Here, we investigated the effects of Gal3 inhibition on cognitive impairment and the possible underlying molecular events in diabetes. We investigated the effects of the Gal3 inhibitor modified citrus pectin (MCP; 100 mg/kg/day oral for 6 weeks) in vivo in high-fat diet (HFD)/ streptozotocin (STZ)-induced diabetic rats. Additionally, the effects of MCP on high glucose (HG)-stimulated BV-2 microglial cells were investigated in vitro. RESULTS: We found that MCP attenuated memory impairment in diabetic rats in the Morris water maze test and reduced insulin resistance, oxidative stress, and neuroinflammation. In HG-stimulated BV-2 microglial cells, MCP increased cell viability and decreased oxidative stress and the production of proinflammatory cytokines. CONCLUSION: The results of this study indicate that the inhibition of Gal3 by MCP ameliorates diabetes-associated cognitive impairment, oxidative stress, and neuroinflammation, suggesting that Gal3 could be a potential new target for therapeutic intervention to prevent cognitive impairment in diabetes.
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Authors | Qingqing Yin, Jian Chen, Shizhan Ma, Chuanfang Dong, Yue Zhang, Xunyao Hou, Shangbin Li, Bin Liu |
Journal | Journal of inflammation research
(J Inflamm Res)
Vol. 13
Pg. 533-542
( 2020)
ISSN: 1178-7031 [Print] New Zealand |
PMID | 32982368
(Publication Type: Journal Article)
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Copyright | © 2020 Yin et al. |