Comparison of antiplatelet antibody profiles between hepatitis C virus-associated immune thrombocytopenia and primary immune thrombocytopenia.

Abstract

Hepatitis C virus-associated immune thrombocytopenia (HCV-ITP) has been assumed to be one of secondary ITP and associated with antiplatelet antibodies. This study was to clarify the antibody profile in HCV-ITP compared with primary ITP. We enrolled 55 HCV-ITP, 30 primary ITP, 11 Helicobacter pylori-ITP, 21 HCV control, and 16 healthy volunteers. We reviewed their blood cell counts, autoimmune markers, and spleen size. We used enzyme-linked immunosorbent assay kit to detect the specific antibody to glycoproteins IIb/IIIa, Ia/IIa, Ib/IX, IV, and human leukocyte antigen (HLA) class I. Compared with primary ITP patients, HCV-ITP patients had an older age, lower white blood cell (WBC) count and fewer presented with severe thrombocytopenia. The rate of positive antibody detection was 63.6% for the HCV-ITP group higher than the rate of 40% for the primary ITP. In the HCV control, antiplatelet antibodies were detected in 38.1% patients and no one had more than two types of antibodies. The antiplatelet antibodies correlated to severer thrombocytopenia. An HLA class I antibody was associated with lower WBCs and larger spleen. In conclusion, HCV-ITP patients had a high rate of positive antiplatelet antibody. The antibodies were associated with not only lower platelets but also leukopenia and splenomegaly.

• Authors: Cih-En Huang, Wei-Ming Chen, Yu-Ying Wu, Chien-Heng Shen, Chia-Chen Hsu, Chian-Pei Li, Min-Chi Chen, Jung-Jung Chang, Yi-Yang Chen, Chang-Hsien Lu, Chung-Sheng Shi, Chih-Cheng Chen
• Journal: Platelets (Platelets) Vol. 32 Issue 8 Pg. 1043-1050 (Nov 17 2021) ISSN: 1369-1635 [Electronic] England
• PMID: 32967492 (Publication Type: Journal Article)

Topics

• Aged
• Blood Platelets (metabolism)
• Case-Control Studies
• Female
• Hepacivirus (immunology)
• Humans
• Male
• Middle Aged
• Purpura, Thrombocytopenic, Idiopathic (blood)
• Thrombocytopenia (blood)