Illuminating Platinum Transportation while Maximizing Therapeutic Efficacy by Gold Nanoclusters via Simultaneous Near-Infrared-I/II Imaging and Glutathione Scavenging.

Abstract

Killing tumor cells with a visualized system is a promising strategy in tumor therapy to achieve minimal side effects and high efficiency. Herein, a theranostic nanomedicine (AuNCs-Pt) is developed based on nanocarrier gold nanoclusters (AuNCs) with bifunctions of both NIR-I/NIR-II imaging and glutathione-scavenging abilities. AuNCs-Pt possesses NIR-II imaging capability on a fatal high-grade serous ovarian cancer (HGSOC) model in the deep abdomen, thus facilitating it to be a promising tool for monitoring platinum transportation. Meanwhile, AuNCs-Pt depletes intracellular glutathione to minimize platinum detoxification, effectively maximizing the chemotherapeutic efficacy of platinum. AuNCs-Pt is used to eradicate the tumor burden in this study on a HGSOC model and a patient-derived tumor xenograft model of hepatocellular carcinoma, suggesting great potential for clinical visualized therapy and platinum drug sensitization.

• Authors: Yuanyuan Yang, Yingjie Yu, Hao Chen, Xiangxi Meng, Wen Ma, Meng Yu, Ziyuan Li, Changhui Li, Haile Liu, Xiaodong Zhang, Haihua Xiao, Zhiqiang Yu
• Journal: ACS nano (ACS Nano) Vol. 14 Issue 10 Pg. 13536-13547 (10 27 2020) ISSN: 1936-086X [Electronic] United States
• PMID: 32924505 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Platinum
• Gold
• Glutathione

Topics

• Glutathione
• Gold
• Humans
• Liver Neoplasms
• Metal Nanoparticles
• Platinum
• Theranostic Nanomedicine