Brain-targeted delivery shuttled by black phosphorus nanostructure to treat Parkinson's disease.

Abstract

The treatment of Parkinson's disease (PD) is hampered by the blood-brain barrier (BBB). As such, there is an urgent need for the development of a novel nanoplatform capable of penetrating the BBB in order to effectively treat PD. In the present study, we utilized black phosphorus nanosheets (BP) containing the brain-targeting ligand lactoferrin (Lf) and loaded with Paeoniflorin (Pae) to obtain Lf-BP-Pae. Through an effective photo-thermal effect, these Lf-BP-Pae particles were capable of traversing the BBB and effectively treating PD in a targeted manner. Importantly, this BP-based nanoplatform was capable of achieving satisfactory biocompatibility and biosafety with excellent anti-Parkinsonian efficacy, making it ideal for clinical applications.

• Authors: Sha Xiong, Zhongjun Li, Yao Liu, Qun Wang, Jingshan Luo, Xiaojia Chen, Zhongjian Xie, Yuan Zhang, Han Zhang, Tongkai Chen
• Journal: Biomaterials (Biomaterials) Vol. 260 Pg. 120339 (11 2020) ISSN: 1878-5905 [Electronic] Netherlands
• PMID: 32861017 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2020 Elsevier Ltd. All rights reserved.

Chemical References

• Phosphorus
• Lactoferrin

Topics

• Blood-Brain Barrier
• Brain
• Drug Delivery Systems
• Humans
• Lactoferrin
• Nanoparticles
• Nanostructures
• Parkinson Disease (drug therapy)
• Phosphorus (therapeutic use)