Clinically Integrated Sequencing Alters Therapy in Children and Young Adults With High-Risk Glial Brain Tumors.
Abstract | PURPOSE:
Brain tumors have become the leading cause of cancer-related mortality in young patients. Novel effective therapies on the basis of the unique biology of each tumor are urgently needed. The goal of this study was to evaluate the feasibility, utility, and clinical impact of integrative clinical sequencing and genetic counseling in children and young adults with high-risk brain tumors. PATIENTS AND METHODS: Fifty-two children and young adults with brain tumors designated by the treating neuro-oncologist to be high risk (> 25% chance for treatment failure; mean age, 10.2 years; range, 0 to 39 years) were enrolled in a prospective, observational, consecutive case series, in which participants underwent integrative clinical exome ( tumor and germline DNA) and transcriptome ( tumor RNA) sequencing and genetic counseling. Results were discussed in a multi-institutional brain tumor precision medicine teleconference. RESULTS: CONCLUSION: Selection of personalized agents for children and young adults with highrisk brain tumors on the basis of integrative clinical sequencing is feasible and resulted in a change in therapy in more than two thirds of children and young adults with high-risk glial tumors.
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Authors | Carl Koschmann, Yi-Mi Wu, Chandan Kumar-Sinha, Robert Lonigro, Pankaj Vats, Katayoon Kasaian, Marcin Cieslik, Xuhong Cao, Bailey Anderson, Kevin Frank, Lili Zhao, John R Prensner, Andrew H Zureick, Jessica Everett, Brendan Mullan, Bernard Marini, Sandra Camelo-Piragua, Sriram Venneti, Paul McKeever, Kathryn McFadden, Andrew P Lieberman, Marcia Leonard, Cormac O Maher, Hugh Garton, Karin Muraszko, Patricia Robertson, Dan Robinson, Arul M Chinnaiyan, Rajen Mody |
Journal | JCO precision oncology
(JCO Precis Oncol)
Vol. 2
( 2018)
ISSN: 2473-4284 [Electronic] United States |
PMID | 32832832
(Publication Type: Journal Article)
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