Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)

Specific receptors on cell membranes that react with PLATELET-DERIVED GROWTH FACTOR, its analogs, or antagonists. The alpha PDGF receptor (RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA) and the beta PDGF receptor (RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA) are the two principle types of PDGF receptors. Activation of the protein-tyrosine kinase activity of the receptors occurs by ligand-induced dimerization or heterodimerization of PDGF receptor types.

Also Known As:

Networked: 1433 relevant articles (54 outcomes, 144 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fidler, Isaiah J: 18 articles (01/2009 - 11/2002)
2.	Heinrich, Michael C: 14 articles (09/2015 - 05/2002)
3.	Ostman, Arne: 14 articles (02/2013 - 10/2002)
4.	Kitadai, Yasuhiko: 13 articles (02/2015 - 11/2005)
5.	Kazlauskas, Andrius: 12 articles (07/2015 - 09/2002)
6.	Mathew, Paul: 12 articles (07/2013 - 03/2003)
7.	Fletcher, Jonathan A: 11 articles (08/2015 - 12/2003)
8.	Cross, Nicholas C P: 11 articles (07/2013 - 01/2002)
9.	Heldin, Carl-Henrik: 10 articles (01/2013 - 10/2002)
10.	Paulsson, Janna: 9 articles (07/2015 - 09/2005)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2013 - "Inhibition of PDGF receptor signaling has proven to useful for the treatment of patients with certain rare tumors. " 11/01/2014 - "The purpose of the study was to evaluate safety and determine the maximum tolerated dose (MTD) of MEDI-575, a fully human monoclonal antibody that selectively binds to platelet-derived growth factor receptor-α (PDGFRα), in patients with advanced solid tumors. " 03/01/2014 - "A phase I study of olaratumab, an anti-platelet-derived growth factor receptor alpha (PDGFRα) monoclonal antibody, in patients with advanced solid tumors." 12/01/2011 - "This study was aimed to explore the applicable value of multiplex nested reverse transcription-polymerase chain reaction (multiplex nested RT-PCR)for the detection of platelet-derived growth factor receptor alpha (PDGFRα) fusion gene in myeloproliferative neoplasms (MPN). " 05/01/2009 - "Microarray studies revealed that platelet-derived growth factor receptor alpha polypeptide (Pdgfr-alpha) was highly expressed in tumor cells compared with NOG8 cells. "
2.	Fibrosis (Cirrhosis) 12/01/2008 - "RNA interference targeting the platelet-derived growth factor receptor beta subunit ameliorates experimental hepatic fibrosis in rats." 11/01/2008 - "Targeted inhibition of platelet-derived growth factor receptor-beta subunit in hepatic stellate cells ameliorates hepatic fibrosis in rats." 11/01/2015 - "Platelet-derived growth factor receptor β (PDGFRβ) immunohistochemistry highlights activated bone marrow stroma and is potentially predictive for fibrosis progression in prefibrotic myeloproliferative neoplasia." 07/01/2015 - "β-PDGF receptor expressed by hepatic stellate cells regulates fibrosis in murine liver injury, but not carcinogenesis." 04/01/2014 - "Mesenchymal fibro-adipogenic progenitors (FAPs) expressing the platelet-derived growth factor receptor alpha (PDGFRα) are an important source of fibrosis and adipogenesis in dystrophic skeletal muscle. "
3.	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 05/01/2011 - "To study the immunophenotype and c-kit or platelet derived growth factor receptor alpha (PDGFRA) gene mutations in CD117-negative gastrointestinal stromal tumors (GISTs). " 09/01/2008 - "To analyze the frequency and spectrum of KIT and platelet-derived growth factor receptor-alpha (PDGFRA) gene in a large series of study and to explore the clinical implication of mutations in the gastrointestinal stromal tumors (GISTs) in China. " 06/01/2006 - "The goal of this study was to investigate the association of mutations in the KIT gene and the platelet-derived growth factor receptor alpha (PDGFRA) gene with clinicopathological features of patients with gastrointestinal stromal tumor (GIST) localized in the stomach. " 09/01/2015 - "Gastrointestinal stromal tumors (GISTs) were originally thought to harbor either KIT or platelet-derived growth factor receptor A (PDGFRA) mutations only. " 08/01/2015 - "Platelet-Derived Growth Factor Receptor-α Regulates Proliferation of Gastrointestinal Stromal Tumor Cells With Mutations in KIT by Stabilizing ETV1."
4.	Inflammation 04/01/2013 - "In cirrhotic liver, most platelets were present in the sinusoidal space of the periportal area with inflammation, where HSCs expressing PDGF receptor-β were frequently observed. " 12/01/1989 - "Platelet-derived growth factor receptors in the kidney--upregulated expression in inflammation." 03/01/1988 - "Expression of platelet-derived growth factor receptors is induced on connective tissue cells during chronic synovial inflammation." 08/01/2009 - "We hypothesized that c-kit and PDGF receptor inhibition may decrease bronchial inflammation and interfere with airway remodeling, which are crucial features of severe asthma. " 03/01/1988 - "The finding that PDGF receptor expression is induced in conjunction with the chronic synovial inflammation associated with rheumatoid arthritis and some other forms of arthritides suggests that PDGF may play a role in the stimulation of mesenchymal cell proliferation that often accompanies chronic inflammatory disease."
5.	Glioma (Gliomas) 09/01/2015 - "Platelet-derived growth factor receptor (PDGFR) signaling plays an important role in the biology of malignant gliomas. " 01/01/2015 - "Double minute amplification of mutant PDGF receptor α in a mouse glioma model." 11/01/2014 - "Whether an aberrant activation of the PDGF receptor pathway is a driving force in glioma development has remained an open question. " 02/15/2014 - "Large numbers of PDGF receptor-α (PDGFRα)-expressing stromal cells derived from oligodendrocytes progenitor cells (OPC) were discovered at the invasive front of high-grade gliomas, in which they exhibited a unique perivascular distribution. " 12/15/2013 - "Here we demonstrate that FACS-sorted malignant glioma-derived pericytes (HMGP) were characterized by the expression of CD90, CD248, and platelet-derived growth factor receptor-β (PDGFR-β). "

Related Drugs and Biologics

1.	imatinib (Gleevec)
2.	Phosphotransferases (Kinase)
3.	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)
4.	Protein-Tyrosine Kinases (Tyrosine Kinase)
5.	Tyrosine (L-Tyrosine)
6.	Platelet-Derived Growth Factor
7.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
8.	tyrosine receptor (receptor, tyrosine)
9.	Epidermal Growth Factor Receptor (EGF Receptor)
10.	Platelet-Derived Growth Factor beta Receptor (Receptor, Platelet Derived Growth Factor beta)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Transplants (Transplant)
4.	Radioimmunotherapy
5.	Therapeutics