Abstract | RESEARCH QUESTION: METHODS: In this prospective pilot cohort study, lncRNA were measured in serum in 13 non-obese women with PCOS and 10 control women undergoing IVF. RESULTS: There was no difference between groups in terms of age, body mass index or insulin resistance. Women with PCOS showed a higher free androgen index (FAI; P = 0.03) and anti-Müllerian hormone (AMH) concentration (P = 0.001). A total of 29 lncRNA (P ≤ 0.05) differed between PCOS groups. lncRNA AC095350.1 correlated with age (r = 0.79, P = 0.04), but no correlation was seen between the significantly different lncRNA and FAI or AMH values. Functional pathway assessment using the Ingenuity Pathway Assessment tool showed no relationships for the lncRNA. CONCLUSION:
lncRNA in serum differed between non-obese women with PCOS and the control group, and the pattern of expression differed from that reported in obese women with PCOS from the same ethnic population; however, it but did not correlate with androgen or insulin resistance.
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Authors | Alexandra E Butler, Shahina Hayat, Soha R Dargham, Joel A Malek, Silvana A Abdullah, Yasmin A Mahmoud, Thozhukat Sathyapalan, Stephen L Atkin |
Journal | Reproductive biomedicine online
(Reprod Biomed Online)
Vol. 41
Issue 4
Pg. 579-583
(Oct 2020)
ISSN: 1472-6491 [Electronic] Netherlands |
PMID | 32819839
(Publication Type: Journal Article)
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Copyright | Copyright © 2020 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
- Blood Glucose
- Insulin
- RNA, Long Noncoding
- Testosterone
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Topics |
- Adult
- Blood Glucose
- Body Mass Index
- Case-Control Studies
- Female
- Humans
- Hyperandrogenism
(blood, genetics, metabolism)
- Insulin
(blood)
- Insulin Resistance
(physiology)
- Polycystic Ovary Syndrome
(blood, genetics, metabolism)
- Prospective Studies
- RNA, Long Noncoding
(genetics, metabolism)
- Testosterone
(blood)
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