Abstract | AIM: To analyze the levels of B-cell-produced antibodies in the vitreous humor of patients with or without diabetic retinopathy (DR) both qualitatively and quantitatively. METHODS: RESULTS: The concentrations of IgA, IgM, and total antibodies in the DR group were significantly higher than those in the control group (all p < 0.001), but there was no significant difference in the 4 IgG subtypes between the two groups after Bonferroni correction. Pearson's correlation analysis revealed low negative correlations between levels of antibodies ( IgA, IgM) and estimated glomerular filtration rate (eGFR, r = -0.443, r = -0.377, respectively, both p < 0.05). Furthermore, multiple linear regression analysis yielded three equations to predict the concentrations of IgA, IgM, and total antibodies in the vitreous humor according to eGFR and other clinical variables (r = 0.542, r = 0.461, and r = 0.312, respectively, all p < 0.05). CONCLUSION: Increased levels of IgA, IgM, and total antibodies produced by B cells were observed in the vitreous humor of T2DM patients with DR. There were low negative correlations between levels of antibodies ( IgA, IgM) and eGFR.
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Authors | Baoyi Liu, Yijun Hu, Qiaowei Wu, Yunkao Zeng, Yu Xiao, Xiaomin Zeng, Ying Fang, Liang Zhang, Tao Li, Honghua Yu |
Journal | Journal of diabetes research
(J Diabetes Res)
Vol. 2020
Pg. 4631290
( 2020)
ISSN: 2314-6753 [Electronic] England |
PMID | 32714992
(Publication Type: Journal Article)
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Copyright | Copyright © 2020 Baoyi Liu et al. |
Chemical References |
- Immunoglobulin A
- Immunoglobulin G
- Immunoglobulin M
|
Topics |
- Adult
- Aged
- B-Lymphocytes
(immunology)
- Diabetes Mellitus, Type 2
(immunology)
- Diabetic Retinopathy
(immunology)
- Female
- Humans
- Immunoglobulin A
(analysis)
- Immunoglobulin G
(analysis)
- Immunoglobulin M
(analysis)
- Male
- Middle Aged
- Vitreous Body
(immunology)
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