Fluoropyrimidine plus
platinum (FP) are chemotherapeutic drugs that are most frequently used to treat
esophageal squamous cell carcinoma (ESCC). However, drug resistance often occurs, and the mechanisms of resistance to
5-FU is yet to be determined. The role of micro (mi)RNAs has been well established in a variety of human
cancers. The aim of the present study was to investigate the expression profile of ESCC, revealing the differential expression between ESCC and
5-FU resistant ESCC. The establishment of a
5-FU resistant (5-FUR) cell lines model provides a way of analyzing the expression of
miRNAs in drug resistance. The
miRNA expression indicated 50
miRNAs that were upregulated in TE10-5-FUR compared with TE10, while 119
miRNAs were downregulated. The TE11-5-FUR demonstrated 140
miRNAs were upregulated compared with TE11, which exhibited 12 downregulated
miRNAs. Both cell lines share the 2 candidate upregulated
miRNAs (miR-146a and miR-483-5p) and 5 downregulated
miRNAs (miR-34a, miR-141, miR-200b, miR-200c and miR-205). Further studies are required to analyze and evaluate the function of the
miRNAs.