Coexisting systemic and organ-specific autoimmunity in MOG-IgG1-associated disorders versus AQP4-IgG+ NMOSD.

Abstract

Aquaporin-4 (AQP4) neuromyelitis optica spectrum disorder (NMOSD) has been demonstrated to be associated with non-organ and organ-specific autoantibodies (antinuclear antibody, extractable nuclear antibody, double-stranded DNA, muscle acetylcholine receptor antibody) and systemic autoimmune diseases. In this study, we evaluated whether a similar association with non-organ and organ-specifc autoantibodies occurs in patients with MOG-IgG1-associated disorders. We determined that MOG-IgG1 was not strongly associated with these organ and non-organ-specific autoantibodies. Systemic lupus erythematous (SLE) was significantly associated with AQP4-IgG+ NMOSD and not with MOGAD (p = 0.037). These findings suggest differences in co-existing systemic and organ-specific autoimmunity between MOGAD and AQP4-IgG+ NMOSD.

• Authors: Amy Kunchok, Eoin P Flanagan, Melissa Snyder, Ruba Saadeh, John J Chen, Brian G Weinshenker, Andrew McKeon, Sean J Pittock
• Journal: Multiple sclerosis (Houndmills, Basingstoke, England) (Mult Scler) Vol. 27 Issue 4 Pg. 630-635 (04 2021) ISSN: 1477-0970 [Electronic] England
• PMID: 32633603 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Aquaporin 4
• Autoantibodies
• Immunoglobulin G
• Myelin-Oligodendrocyte Glycoprotein

Topics

• Aquaporin 4
• Autoantibodies
• Autoimmunity
• Humans
• Immunoglobulin G
• Myelin-Oligodendrocyte Glycoprotein
• Neuromyelitis Optica