The combined administration of thymomodulin and interleukin 2 reverses T-cell unresponsiveness in mice infected with Mycobacterium bovis-BCG.

Abstract

Mice infected intravenously with high doses of M. bovis, strain BCG, showed a marked impairment of delayed-type hypersensitivity to PPD evaluated in in vivo skin tests and in vitro as splenocyte blast transformation. However, this state of unresponsiveness could be partially reversed after 1 month of infection by the intraperitoneal injection of a calf thymus acid lysate (thymomodulin). Furthermore, BCG-infected mice treated in vivo simultaneously with both thymomodulin and interleukin 2 immediately developed positive skin reactions and blast transformation to PPD and did not become anergic in the course of infection.

• Authors: V Colizzi, P Cazzola, P Mazzanti
• Journal: International journal of immunopharmacology (Int J Immunopharmacol) Vol. 10 Issue 3 Pg. 271-5 ( 1988) ISSN: 0192-0561 [Print] England
• PMID: 3263332 (Publication Type: Journal Article)

Chemical References

• Interleukin-2
• Thymus Extracts
• thymomodulin

Topics

• Animals
• Cell Division (drug effects)
• Drug Therapy, Combination
• Hypersensitivity, Delayed
• Interleukin-2 (administration & dosage, pharmacology)
• Mice
• Mice, Inbred CBA
• Mycobacterium Infections (drug therapy)
• T-Lymphocytes (drug effects)
• Thymus Extracts (administration & dosage, pharmacology)