FOLFIRINOX Versus Gemcitabine-based Therapy for Pancreatic Ductal Adenocarcinoma: Lessons from Patient-derived Cell Lines.

Abstract

BACKGROUND/AIM:

FOLFIRINOX [fluorouracil (5-FU), irinotecan, oxaliplatin] and gemcitabine plus nab-paclitaxel are standard treatments for patients with pancreatic ductal adenocarcinoma (PDAC). Despite efficacy rates of less than 32%, evidence is lacking to guide the use of one drug over the other. Herein, we compared the sensitivity of patient-derived PDAC cell lines to each of these regimens.

MATERIALS AND METHODS:

Changes in the growth of 19 low-passage patient-derived PDAC cell lines were evaluated in response to treatment with FOLFIRINOX and gemcitabine plus paclitaxel (Gem-Pac).

RESULTS:

Six cell lines exhibited optimal sensitivity (high EMax and low GI50) to FOLFIRINOX and three cell lines exhibited optimal sensitivity to Gem-Pac. Several cell lines that were optimally sensitive to one drug regimen exhibited very poor response to the other.

CONCLUSION:

Further characterization of cancer cells exhibiting preferential sensitivity to each of these regimens may allow the identification of biomarkers to guide the selection of appropriate chemotherapy for a given patient.

• Authors: Sebastian K S Begg, David J Birnbaum, Jeffrey W Clark, Mari Mino-Kenudson, Ulrich F Wellner, Oliver Schilling, Keith D Lillemoe, Andrew L Warshaw, Carlos FernÁndez-Del Castillo, Andrew S Liss
• Journal: Anticancer research (Anticancer Res) Vol. 40 Issue 7 Pg. 3659-3667 (Jul 2020) ISSN: 1791-7530 [Electronic] Greece
• PMID: 32620605 (Publication Type: Journal Article)
• Copyright: Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• folfirinox
• Oxaliplatin
• Deoxycytidine
• Irinotecan
• Leucovorin
• Fluorouracil
• Gemcitabine

Topics

• Adenocarcinoma (drug therapy)
• Adult
• Aged
• Aged, 80 and over
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Carcinoma, Pancreatic Ductal (drug therapy)
• Cell Line, Tumor
• Deoxycytidine (analogs & derivatives, therapeutic use)
• Female
• Fluorouracil (therapeutic use)
• Humans
• Irinotecan (therapeutic use)
• Leucovorin (therapeutic use)
• Male
• Middle Aged
• Oxaliplatin (therapeutic use)
• Pancreatic Neoplasms (drug therapy)
• Gemcitabine
• Pancreatic Neoplasms