Tripartite motif 5 (TRIM5) plays a significant function in autophagy and involves in immune and
tumor processes. While the function of TRIM5 remains poorly understood in
glioma. We purpose to evaluate the possible prognostic role of TRIM5 in
glioma via bioinformatics analyses. The database clinical samples of
glioma in this study included low grade
glioma (LGG) and
glioblastoma multiforme (GBM). TRIM5 expression in
glioma tissues were explored in Oncomine, GEPIA and The
Cancer Genome Atlas (TCGA) databases. Survival analysis and the multivariate Cox regression analysis of TRIM5 based on TCGA were used to evaluate the prognostic role of TRIM5. The
protein networks of TRIM5 was detected by STRING database. KEGG enrichment analyses were performed to predict the potential molecular pathways of TRIM5 in
glioma. In addition, immune infiltration analysis was conducted by CIBERSORT and TIMER databases. We found that TRIM5 was strongly increased in
glioma samples compared with normal samples in Oncomine, GEPIA and TCGA databases. Higher TRIM5 was significantly contributed to worse overall survival (OS) in LGG+GBM patients and LGG patients, while was no correlated with OS of GBM patients. Interaction networks analysis identified that IRF3, IRF7, OAS1, OAS2, OAS3, OASL, GBP1, PML, BTBD1 and BTBD2
proteins were contacted with TRIM5. Moreover, KEGG revealed that apoptosis and
cancer- and immune-related pathways were enriched with elevated TRIM5. Specifically, TRIM5 could influence the immune infiltration levels, such as activated NK cells, monocytes, activated mast cells and macrophages in
glioma. In conclusion, our data indicated that TRIM5 was upregulated in
glioma tissues and associated with poor prognosis and immune infiltration. TRIM5 may be acted as a
biomarker in prognosis and
immunotherapy guidance of
glioma.