Abstract | BACKGROUND: AIMS: To better understand the role of butorphanol in the treatment of cholestatic pruritus, including characterization of its side effect profile. METHODS: We present a case series of eight adult patients with cholestatic disease who were treated with butorphanol in hopes of alleviating intractable pruritus. Patients were identified through a clinical data request form serviced by University of Miami Information Technology. RESULTS: CONCLUSIONS:
Butorphanol was safe and leads to clinically significant symptomatic improvement. Clinicians should be aware of butorphanol as an off-label treatment option for pruritus of cholestasis. Further studies are needed to better characterize the effect of butorphanol on cholestatic itch.
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Authors | Rachel Shireen Golpanian, Gil Yosipovitch, Cynthia Levy |
Journal | Digestive diseases and sciences
(Dig Dis Sci)
Vol. 66
Issue 5
Pg. 1693-1699
(05 2021)
ISSN: 1573-2568 [Electronic] United States |
PMID | 32556969
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antipruritics
- Butorphanol
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Topics |
- Adult
- Aged
- Antipruritics
(adverse effects, therapeutic use)
- Butorphanol
(adverse effects, therapeutic use)
- Cholestasis
(complications, diagnosis)
- Female
- Humans
- Male
- Middle Aged
- Pruritus
(diagnosis, drug therapy, etiology)
- Remission Induction
- Severity of Illness Index
- Treatment Outcome
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