[Mutltifaceted biological roles of leptin].

Abstract

The identification of leptin allowed the discovery of a new endocrine system. This major adipokine controlling energy homeostasis is also involved in the regulation of neuroendocrine function and fertility. Unfortunately, leptin is not able to treat common obesity, which associates hyperleptinemia and resistance to the hormone. Conversely, treatment with recombinant leptin is effective in situations of leptin deficiency. Several pathophysiological situations associated with adipose tissue dysfunctions and abnormal regulation of leptin secretion are discussed in this review. The advantage of the potential use of the leptin assay in some pathophysiological conditions is proposed.

• Authors: Rim Charchour, Diane Dufour-Rainfray, Gilles Morineau, Camille Vatier, Soraya Fellahi, Corinne Vigouroux, Annelise Genoux, Jacqueline Capeau, Jean-Marc Lacorte, Christine Collet, Charlotte Cuerq, Jean-Philippe Bastard, groupe de travail RIHN Adipokines
• Journal: Annales de biologie clinique (Ann Biol Clin (Paris)) Vol. 78 Issue 3 Pg. 231-242 (06 01 2020) ISSN: 1950-6112 [Electronic] France
• Vernacular Title: Rôles biologiques à multiples facettes de la leptine.
• PMID: 32540812 (Publication Type: Journal Article, Review)

Chemical References

• Adipokines
• Leptin

Topics

• Adipokines (physiology)
• Adipose Tissue (metabolism, physiopathology)
• Animals
• Homeostasis (physiology)
• Humans
• Leptin (physiology)
• Obesity (metabolism, physiopathology)
• Secretory Pathway (physiology)